publication . Article . Other literature type . 2017

Systematic analysis of telomere length and somatic alterations in 31 cancer types

Barthel, Floris P; Wei, Wei; Tang, Ming; Martinez-Ledesma, Emmanuel; Hu, Xin; Amin, Samirkumar B; Akdemir, Kadir C; Seth, Sahil; Song, Xingzhi; Wang, Qianghu; ...
Open Access
  • Published: 30 Jan 2017 Journal: Nature Genetics, volume 49, pages 349-357 (issn: 1061-4036, eissn: 1546-1718, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
Abstract
Cancer cells survive cellular crisis through telomere maintenance mechanisms. We report telomere lengths in 18,430 samples, including tumors and non-neoplastic samples, across 31 cancer types. Tumor telomeres were shorter compared to normal tissues, and longer in sarcomas and gliomas compared to other cancers. Amongst 6,835 cancers, 73% expressed telomerase reverse transcriptase (TERT), which was associated with TERT point mutations, rearrangements, DNA amplifications, and transcript fusions, and predicted telomerase activity. TERT promoter methylation provided an additional deregulatory TERT expression mechanism. Five percent of cases, mostly with undetectable ...
Subjects
free text keywords: Molecular biology, Genetics, Death-associated protein 6, Senescence, Telomere, Biology, Cancer, medicine.disease, medicine, Somatic cell, ATRX, Article
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publication . Article . Other literature type . 2017

Systematic analysis of telomere length and somatic alterations in 31 cancer types

Barthel, Floris P; Wei, Wei; Tang, Ming; Martinez-Ledesma, Emmanuel; Hu, Xin; Amin, Samirkumar B; Akdemir, Kadir C; Seth, Sahil; Song, Xingzhi; Wang, Qianghu; ...