publication . Other literature type . Article . 1999

CHARACTERIZATION OF NONAGGREGATING, NONINFLAMMATORY RANTES MUTANTS

Victor Appay; Anthony Brown; Scott Cribbes; Eliot Randle; Lloyd G. Czaplewski;
Open Access
  • Published: 24 Sep 1999
  • Publisher: American Society for Biochemistry & Molecular Biology (ASBMB)
Abstract
Abstract The biology of RANTES (regulated on activation normal T cell expressed) aggregation has been investigated using RANTES and disaggregated variants, enabling comparison of aggregated, tetrameric, and dimeric RANTES forms. Disaggregated variants retain their Gi-type G protein-coupled receptor-mediated biological activities. A correlation between RANTES aggregation and cellular activation has been demonstrated. Aggregated RANTES, but not disaggregated RANTES, activates human T cells, monocytes, and neutrophils. Dimeric RANTES has lost its cellular activating activity, rendering it noninflammatory. Macrophage inflammatory protein 1α, macrophage inflammatory ...
Subjects
Medical Subject Headings: hemic and immune systems
free text keywords: Cell Biology, Biochemistry, Molecular Biology
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