publication . Article . 2017

Combined Supplementation of Choline and Docosahexaenoic Acid during Pregnancy Enhances Neurodevelopment of Fetal Hippocampus

Huban Thomas Rajarethnem; Kumar Megur Ramakrishna Bhat; Malsawmzuali Jc; Siva Kumar Gopalkrishnan; Ramesh Babu Mugundhu Gopalram; Kiranmai Sesappa Rai;
  • Published: 01 Jan 2017
  • Publisher: Hindawi Limited
Abstract
<jats:p>Choline is an essential nutrient for humans which plays an important role in structural integrity and signaling functions. Docosahexaenoic acid (DHA) is a polyunsaturated fatty acid, highly enriched in cell membranes of the brain. Dietary intake of choline or DHA alone by pregnant mothers directly affects fetal brain development and function. But no studies show the efficacy of combined supplementation of choline and DHA on fetal neurodevelopment. The aim of the present study was to analyze fetal neurodevelopment on combined supplementation of pregnant dams with choline and DHA. Pregnant dams were divided into five groups: normal control [NC], saline con...
Subjects
free text keywords: Article Subject, Research Article, Neurology. Diseases of the nervous system, RC346-429, Neurology, Clinical Neurology, Diabetes mellitus, medicine.disease, medicine, Internal medicine, medicine.medical_specialty, Docosahexaenoic acid, Pregnancy, business.industry, business, Choline, chemistry.chemical_compound, chemistry, Essential nutrient, chemistry.chemical_classification, Hippocampus, Fetus, Polyunsaturated fatty acid, Endocrinology
Related Organizations
48 references, page 1 of 4

Stiles, J., Jernigan, T. L.. The basics of brain development. Neuropsychology Review . 2010; 20 (4): 327-348 [OpenAIRE] [PubMed] [] [DOI]

Raineki, C., Holman, P. J., Debiec, J., Bugg, M., Beasley, A., Sullivan, R. M.. Functional emergence of the hippocampus in context fear learning in infant rats. Hippocampus . 2010; 20 (9): 1037-1046 [OpenAIRE] [PubMed] [] [DOI]

Cohen, N. J., Ryan, J., Hunt, C., Romine, L., Wszalek, T., Nash, C.. Hippocampal system and declarative (Relational) memory: summarizing the data from functional neuroimaging studies. Hippocampus . 1999; 9 (1): 83-98 [OpenAIRE] [PubMed] [] [DOI]

Amaral, D. G.. Emerging principles of intrinsic hippocampal organization. Current Opinion in Neurobiology . 1993; 3 (2): 225-229 [PubMed] [] [DOI]

Insausti, R., Amaral, D. G., Cowan, W. M.. The entorhinal cortex of the monkey: II. Cortical afferents. Journal of Comparative Neurology . 1987; 264 (3): 356-395 [OpenAIRE] [PubMed] [] [DOI]

Suzuki, W. L., Amaral, D. G.. Perirhinal and parahippocampal cortices of the macaque monkey: cortical afferents. Journal of Comparative Neurology . 1994; 350 (4): 497-533 [OpenAIRE] [PubMed] [] [DOI]

Witter, M. P., Amaral, D. G.. Entorhinal cortex of the monkey: V. Projections to the dentate gyrus, hippocampus, and subicular complex. Journal of Comparative Neurology . 1991; 307 (3): 437-459 [OpenAIRE] [PubMed] [] [DOI]

Benes, F. M.. Myelination of cortical-hippocampal relays during late adolescence. Schizophrenia Bulletin . 1989; 15 (4): 585-593 [OpenAIRE] [PubMed] [] [DOI]

Rice, D., Barone, S.. Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. Environmental Health Perspectives . 2000; 108 (supplement 3): 511-533 [OpenAIRE] [PubMed] [] [DOI]

Zeisel, S. H., Blusztajn, J. K.. Choline and human nutrition. Annual Review of Nutrition . 1994; 14: 269-296 [OpenAIRE] [PubMed] [] [DOI]

Zeisel, S. H., Da Costa, K. A., Franklin, P. D.. Choline, an essential nutrient for humans. The FASEB Journal . 1991; 5 (7): 2093-2098 [OpenAIRE] [PubMed] []

da Costa, K.-A., Rai, K. S., Craciunescu, C. N.. Dietary docosahexaenoic acid supplementation modulates hippocampal development in the Pemt−/− mouse. Journal of Biological Chemistry . 2010; 285 (2): 1008-1015 [OpenAIRE] [PubMed] [] [DOI]

DeLong, C. J., Shen, Y.-J., Thomas, M. J., Cui, Z.. Molecular distinction of phosphatidylcholine synthesis between the CDP- choline pathway and phosphatidylethanolamine methylation pathway. Journal of Biological Chemistry . 1999; 274 (42): 29683-29688 [OpenAIRE] [PubMed] [] [DOI]

Innis, S. M.. Dietary (n-3) fatty acids and brain development. Journal of Nutrition . 2007; 137 (4): 855-859 [PubMed] []

Turner, N., Else, P. L., Hulbert, A. J.. Docosahexaenoic acid (DHA) content of membranes determines molecular activity of the sodium pump: implications for disease states and metabolism. Naturwissenschaften . 2003; 90 (11): 521-523 [OpenAIRE] [PubMed] [] [DOI]

48 references, page 1 of 4
Abstract
<jats:p>Choline is an essential nutrient for humans which plays an important role in structural integrity and signaling functions. Docosahexaenoic acid (DHA) is a polyunsaturated fatty acid, highly enriched in cell membranes of the brain. Dietary intake of choline or DHA alone by pregnant mothers directly affects fetal brain development and function. But no studies show the efficacy of combined supplementation of choline and DHA on fetal neurodevelopment. The aim of the present study was to analyze fetal neurodevelopment on combined supplementation of pregnant dams with choline and DHA. Pregnant dams were divided into five groups: normal control [NC], saline con...
Subjects
free text keywords: Article Subject, Research Article, Neurology. Diseases of the nervous system, RC346-429, Neurology, Clinical Neurology, Diabetes mellitus, medicine.disease, medicine, Internal medicine, medicine.medical_specialty, Docosahexaenoic acid, Pregnancy, business.industry, business, Choline, chemistry.chemical_compound, chemistry, Essential nutrient, chemistry.chemical_classification, Hippocampus, Fetus, Polyunsaturated fatty acid, Endocrinology
Related Organizations
48 references, page 1 of 4

Stiles, J., Jernigan, T. L.. The basics of brain development. Neuropsychology Review . 2010; 20 (4): 327-348 [OpenAIRE] [PubMed] [] [DOI]

Raineki, C., Holman, P. J., Debiec, J., Bugg, M., Beasley, A., Sullivan, R. M.. Functional emergence of the hippocampus in context fear learning in infant rats. Hippocampus . 2010; 20 (9): 1037-1046 [OpenAIRE] [PubMed] [] [DOI]

Cohen, N. J., Ryan, J., Hunt, C., Romine, L., Wszalek, T., Nash, C.. Hippocampal system and declarative (Relational) memory: summarizing the data from functional neuroimaging studies. Hippocampus . 1999; 9 (1): 83-98 [OpenAIRE] [PubMed] [] [DOI]

Amaral, D. G.. Emerging principles of intrinsic hippocampal organization. Current Opinion in Neurobiology . 1993; 3 (2): 225-229 [PubMed] [] [DOI]

Insausti, R., Amaral, D. G., Cowan, W. M.. The entorhinal cortex of the monkey: II. Cortical afferents. Journal of Comparative Neurology . 1987; 264 (3): 356-395 [OpenAIRE] [PubMed] [] [DOI]

Suzuki, W. L., Amaral, D. G.. Perirhinal and parahippocampal cortices of the macaque monkey: cortical afferents. Journal of Comparative Neurology . 1994; 350 (4): 497-533 [OpenAIRE] [PubMed] [] [DOI]

Witter, M. P., Amaral, D. G.. Entorhinal cortex of the monkey: V. Projections to the dentate gyrus, hippocampus, and subicular complex. Journal of Comparative Neurology . 1991; 307 (3): 437-459 [OpenAIRE] [PubMed] [] [DOI]

Benes, F. M.. Myelination of cortical-hippocampal relays during late adolescence. Schizophrenia Bulletin . 1989; 15 (4): 585-593 [OpenAIRE] [PubMed] [] [DOI]

Rice, D., Barone, S.. Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. Environmental Health Perspectives . 2000; 108 (supplement 3): 511-533 [OpenAIRE] [PubMed] [] [DOI]

Zeisel, S. H., Blusztajn, J. K.. Choline and human nutrition. Annual Review of Nutrition . 1994; 14: 269-296 [OpenAIRE] [PubMed] [] [DOI]

Zeisel, S. H., Da Costa, K. A., Franklin, P. D.. Choline, an essential nutrient for humans. The FASEB Journal . 1991; 5 (7): 2093-2098 [OpenAIRE] [PubMed] []

da Costa, K.-A., Rai, K. S., Craciunescu, C. N.. Dietary docosahexaenoic acid supplementation modulates hippocampal development in the Pemt−/− mouse. Journal of Biological Chemistry . 2010; 285 (2): 1008-1015 [OpenAIRE] [PubMed] [] [DOI]

DeLong, C. J., Shen, Y.-J., Thomas, M. J., Cui, Z.. Molecular distinction of phosphatidylcholine synthesis between the CDP- choline pathway and phosphatidylethanolamine methylation pathway. Journal of Biological Chemistry . 1999; 274 (42): 29683-29688 [OpenAIRE] [PubMed] [] [DOI]

Innis, S. M.. Dietary (n-3) fatty acids and brain development. Journal of Nutrition . 2007; 137 (4): 855-859 [PubMed] []

Turner, N., Else, P. L., Hulbert, A. J.. Docosahexaenoic acid (DHA) content of membranes determines molecular activity of the sodium pump: implications for disease states and metabolism. Naturwissenschaften . 2003; 90 (11): 521-523 [OpenAIRE] [PubMed] [] [DOI]

48 references, page 1 of 4
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publication . Article . 2017

Combined Supplementation of Choline and Docosahexaenoic Acid during Pregnancy Enhances Neurodevelopment of Fetal Hippocampus

Huban Thomas Rajarethnem; Kumar Megur Ramakrishna Bhat; Malsawmzuali Jc; Siva Kumar Gopalkrishnan; Ramesh Babu Mugundhu Gopalram; Kiranmai Sesappa Rai;