publication . Article . Other literature type . 1997

A pandemic warning?

J. C. de Jong; E. C. J. Claas; A. D. M. E. Osterhaus; R. G. Webster; W. L. Lim;
Open Access English
  • Published: 01 Oct 1997
  • Country: Netherlands
Abstract
Introduction of new influenza type-A viruses, carrying different combinations of the viral envelope glycoproteins haemagglutinin (H) and neuraminidase (N), have led to three major pandemics of influenza in humans this century. Phylogenetic evidence suggests that these viruses have originated from avian influenza A viruses, either unchanged or after reassortment with humaninfluenza A viruses. In aquatic birds, all of the known H and N antigenic varieties (15 varieties carry H, nine carry N envelope glycoproteins) apparently circulate in a genetically conserved fashion. Viruses carrying the H1N1, H2N2 and H3N2 combinations were responsible for the Spanish flu of 1...
Subjects
Medical Subject Headings: virus diseasesviruses
free text keywords: *Influenza A virus/classification/genetics/isolation & purification, 0 (HN Protein), HN Protein/genetics, Human, Infant, Influenza/*epidemiology/virology, Male, Phylogeny, Article, Multidisciplinary, Influenza A virus, medicine.disease_cause, medicine, Reassortment, Human mortality from H5N1, Influenza A (H5N1) Virus, Antigenic shift, Pandemic, H5N1 genetic structure, Influenza A virus subtype H5N1, Virology, Biology
Related Organizations

Webster, RG. Microb. Rev.. 1992: 152-179

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publication . Article . Other literature type . 1997

A pandemic warning?

J. C. de Jong; E. C. J. Claas; A. D. M. E. Osterhaus; R. G. Webster; W. L. Lim;