publication . Other literature type . Article . 2002

Stochastic Gene Expression in a Single Cell

Peter S. Swain;
Open Access
  • Published: 16 Aug 2002
  • Publisher: American Association for the Advancement of Science (AAAS)
Clonal populations of cells exhibit substantial phenotypic variation. Such heterogeneity can be essential for many biological processes and is conjectured to arise from stochasticity, or noise, in gene expression. We constructed strains of Escherichia coli that enable detection of noise and discrimination between the two mechanisms by which it is generated. Both stochasticity inherent in the biochemical process of gene expression (intrinsic noise) and fluctuations in other cellular components (extrinsic noise) contribute substantially to overall variation. Transcription rate, regulatory dynamics, and genetic factors control the amplitude of noise. These results ...
free text keywords: Multidisciplinary
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Article . 2002
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Other literature type . 2002
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