publication . Article . Other literature type . 2011

Requirements for effective malaria control with homing endonuclease genes

Deredec, A.; Godfray, H. C. J.; Burt, A.;
Open Access
  • Published: 05 Oct 2011 Journal: Proceedings of the National Academy of Sciences, volume 108, pages E874-E880 (issn: 0027-8424, eissn: 1091-6490, Copyright policy)
  • Publisher: Proceedings of the National Academy of Sciences
Abstract
Malaria continues to impose a substantial burden on human health. We have previously proposed that biological approaches to control the mosquito vector of disease could be developed using homing endonuclease genes (HEGs), a class of selfish or parasitic gene that exists naturally in many microbes. Recent lab studies have demonstrated that HEGs can function in mosquitoes. We constructed and analyzed a model of mosquito population genetics and malaria epidemiology to determine how well HEGs need to function in order to have a significant effect on the burden of disease. Our model, combined with currently available data, indicates that populations of Anopheles gamb...
Subjects
free text keywords: Multidisciplinary, Malaria, medicine.disease, medicine, Disease, Population, education.field_of_study, education, Homing endonuclease, biology.protein, biology, Population genetics, Genetics, Anopheles gambiae, biology.organism_classification, Gene drive, Vector (epidemiology), biological control, genetic load, vector control, [SDV]Life Sciences [q-bio], [SDE]Environmental Sciences, PNAS Plus, biological control;genetic load;vector control
38 references, page 1 of 3

1. WHO-Global-Malaria-Programme (2010) World Malaria Report (World Health Organisation, Geneva).

2. Mendis K, et al. (2009) From malaria control to eradication: The WHO perspective. Trop Med Int Health 14:802-809.

3. O'Meara WP, et al. (2008) Effect of a fall in malaria transmission on morbidity and mortality in Kilifi, Kenya. Lancet 372:1555-1562. [OpenAIRE]

4. James AA (2005) Gene drive systems in mosquitoes: Rules of the road. Trends Parasitol 21:64-67.

5. Marshall JM, Taylor CE (2009) Malaria control with transgenic mosquitoes. PLoS Med 6:e1000020.

6. Burt A, Koufopanou V (2004) Homing endonuclease genes: The rise and fall and rise again of a selfish element. Curr Opin Genet Dev 14:609-615. [OpenAIRE]

7. Stoddard BL (2005) Homing endonuclease structure and function. Q Rev Biophys 38:49-95.

8. Burt A (2003) Site-specific selfish genes as tools for the control and genetic engineering of natural populations. Proc R Soc Lond B Biol Sci 270:921-928.

9. Deredec A, Burt A, Godfray HCJ (2008) The population genetics of using homing endonuclease genes in vector and pest management. Genetics 179:2013-2026. [OpenAIRE]

10. Chan Y-S, Huen DS, Russell S (2011) Characterisation of a homing endonuclease-based drive system in Drosophila melanogaster. Genetics 188:33-44.

11. Windbichler N, et al. (2011) A synthetic homing endonuclease-based gene drive system in the human malaria mosquito. Nature 473:212-215.

12. Windbichler N, Papathanos PA, Crisanti A (2008) Targeting the X chromosome during spermatogenesis induces Y chromosome transmission ratio distortion and early dominant embryo lethality in Anopheles gambiae. PloS Genet 4:e1000291.

13. Baker DA, et al. (2011) A comprehensive gene expression atlas of sex- and tissuespecificity in the malaria vector, Anopheles gambiae. BMC Genomics 12:296.

14. MacDonald G (1957) The Epidemiology and Control of Malaria (Oxford Univ Press, London).

15. Read AF, Lynch PA, Thomas MB (2009) How to make evolution-proof insecticides for malaria control. PloS Biol 7:e1000058.

38 references, page 1 of 3
Abstract
Malaria continues to impose a substantial burden on human health. We have previously proposed that biological approaches to control the mosquito vector of disease could be developed using homing endonuclease genes (HEGs), a class of selfish or parasitic gene that exists naturally in many microbes. Recent lab studies have demonstrated that HEGs can function in mosquitoes. We constructed and analyzed a model of mosquito population genetics and malaria epidemiology to determine how well HEGs need to function in order to have a significant effect on the burden of disease. Our model, combined with currently available data, indicates that populations of Anopheles gamb...
Subjects
free text keywords: Multidisciplinary, Malaria, medicine.disease, medicine, Disease, Population, education.field_of_study, education, Homing endonuclease, biology.protein, biology, Population genetics, Genetics, Anopheles gambiae, biology.organism_classification, Gene drive, Vector (epidemiology), biological control, genetic load, vector control, [SDV]Life Sciences [q-bio], [SDE]Environmental Sciences, PNAS Plus, biological control;genetic load;vector control
38 references, page 1 of 3

1. WHO-Global-Malaria-Programme (2010) World Malaria Report (World Health Organisation, Geneva).

2. Mendis K, et al. (2009) From malaria control to eradication: The WHO perspective. Trop Med Int Health 14:802-809.

3. O'Meara WP, et al. (2008) Effect of a fall in malaria transmission on morbidity and mortality in Kilifi, Kenya. Lancet 372:1555-1562. [OpenAIRE]

4. James AA (2005) Gene drive systems in mosquitoes: Rules of the road. Trends Parasitol 21:64-67.

5. Marshall JM, Taylor CE (2009) Malaria control with transgenic mosquitoes. PLoS Med 6:e1000020.

6. Burt A, Koufopanou V (2004) Homing endonuclease genes: The rise and fall and rise again of a selfish element. Curr Opin Genet Dev 14:609-615. [OpenAIRE]

7. Stoddard BL (2005) Homing endonuclease structure and function. Q Rev Biophys 38:49-95.

8. Burt A (2003) Site-specific selfish genes as tools for the control and genetic engineering of natural populations. Proc R Soc Lond B Biol Sci 270:921-928.

9. Deredec A, Burt A, Godfray HCJ (2008) The population genetics of using homing endonuclease genes in vector and pest management. Genetics 179:2013-2026. [OpenAIRE]

10. Chan Y-S, Huen DS, Russell S (2011) Characterisation of a homing endonuclease-based drive system in Drosophila melanogaster. Genetics 188:33-44.

11. Windbichler N, et al. (2011) A synthetic homing endonuclease-based gene drive system in the human malaria mosquito. Nature 473:212-215.

12. Windbichler N, Papathanos PA, Crisanti A (2008) Targeting the X chromosome during spermatogenesis induces Y chromosome transmission ratio distortion and early dominant embryo lethality in Anopheles gambiae. PloS Genet 4:e1000291.

13. Baker DA, et al. (2011) A comprehensive gene expression atlas of sex- and tissuespecificity in the malaria vector, Anopheles gambiae. BMC Genomics 12:296.

14. MacDonald G (1957) The Epidemiology and Control of Malaria (Oxford Univ Press, London).

15. Read AF, Lynch PA, Thomas MB (2009) How to make evolution-proof insecticides for malaria control. PloS Biol 7:e1000058.

38 references, page 1 of 3
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