publication . Article . 2017

How driving endonuclease genes can be used to combat pests and disease vectors

Godfray, H. Charles J.; North, Ace; Burt, Austin;
Open Access English
  • Published: 01 Sep 2017
  • Publisher: BioMed Central
  • Country: United Kingdom
Abstract
Driving endonuclease genes (DEGs) spread through a population by a non-Mendelian mechanism. In a heterozygote, the protein encoded by a DEG causes a double-strand break in the homologous chromosome opposite to where its gene is inserted and when the break is repaired using the homologue as a template the DEG heterozygote is converted to a homozygote. Some DEGs occur naturally while several classes of endonucleases can be engineered to spread in this way, with CRISPR-Cas9 based systems being particularly flexible. There is great interest in using driving endonuclease genes to impose a genetic load on insects that vector diseases or are economic pests to reduce th...
Subjects
Medical Subject Headings: genetic structures
free text keywords: Science & Technology, Life Sciences & Biomedicine, Biology, Life Sciences & Biomedicine - Other Topics, Gene drive, Gene editing, Endonucleases, CRISPR-Cas9, Vector control, Pest control, Mosquitoes, HOMING ENDONUCLEASE, ANOPHELES-GAMBIAE, SEX-RATIO, NATURAL-POPULATIONS, MALARIA MOSQUITO, AEDES-AEGYPTI, DYNAMICS, SYSTEM, REQUIREMENTS, ELIMINATION, 06 Biological Sciences, Developmental Biology, Biology (General), QH301-705.5, Review, Genetics, biology.protein, Gene, Genome editing, Genetic load, CRISPR, Population genetics, Population, education.field_of_study, education
Related Organizations
62 references, page 1 of 5

Sinkins, SP, Gould, F. Gene drive systems for insect disease vectors. Nat Rev Genet. 2006; 7 (6): 427-35 [OpenAIRE] [PubMed] [DOI]

Burt, A. Heritable strategies for controlling insect vectors of disease. Philos Trans R Soc B Biol Sci. 2014; 369 (1656): 20130432 [OpenAIRE] [DOI]

3.Esvelt KM, Smidler AL, Catteruccia F, Church GM. Concerning RNA-guided gene drives for the alteration of wild populations. Elife. 2014;3:e03401.

Champer, J, Buchman, A, Akbari, OS. Cheating evolution: engineering gene drives to manipulate the fate of wild populations. Nat Rev Genet. 2016; 17 (3): 146-59 [OpenAIRE] [PubMed] [DOI]

Gantz, VM, Bier, E. The dawn of active genetics. Bioessays. 2016; 38 (1): 50-63 [OpenAIRE] [PubMed] [DOI]

Alphey, L. Can CRISPR-Cas9 gene drives curb malaria?. Nat Biotechnol. 2016; 34 (2): 149-50 [OpenAIRE] [PubMed] [DOI]

Adelman, ZN, Tu, ZJ. Control of mosquito-borne infectious diseases: sex and gene drive. Trends Parasitol. 2016; 32 (3): 219-29 [OpenAIRE] [PubMed] [DOI]

Leftwich, PT, Bolton, M, Chapman, T. Evolutionary biology and genetic techniques for insect control. Evol Appl. 2016; 9 (1): 212-30 [OpenAIRE] [PubMed] [DOI]

Craig, GB, Hickey, WA, van de Hey, RC. An inherited male-producing factor in Aedes aegypti. Science. 1960; 132: 1887-9 [OpenAIRE] [PubMed] [DOI]

Hickey, WA, Craig, GB. Genetic distortion of sex ratio in a mosquito, Aedes aegypti. Genetics. 1966; 53: 1177-96 [OpenAIRE] [PubMed]

Curtis, CF. Possible use of translocations to fix desirable genes in insect pest populations. Nature. 1968; 218: 368-9 [OpenAIRE] [PubMed] [DOI]

Hamilton, WD. Extraordinary sex ratios. Science. 1967; 156: 477-88 [OpenAIRE] [PubMed] [DOI]

Burt, A, Trivers, R. Genes in conflict. 2006

Stoddard, BL. Homing endonuclease structure and function. Q Rev Biophys. 2005; 38 (1): 49-95 [PubMed] [DOI]

Burt, A. Site-specific selfish genes as tools for the control and genetic engineering of natural populations. Proc Biol Sci. 2003; 270 (1518): 921-8 [OpenAIRE] [PubMed] [DOI]

62 references, page 1 of 5
Abstract
Driving endonuclease genes (DEGs) spread through a population by a non-Mendelian mechanism. In a heterozygote, the protein encoded by a DEG causes a double-strand break in the homologous chromosome opposite to where its gene is inserted and when the break is repaired using the homologue as a template the DEG heterozygote is converted to a homozygote. Some DEGs occur naturally while several classes of endonucleases can be engineered to spread in this way, with CRISPR-Cas9 based systems being particularly flexible. There is great interest in using driving endonuclease genes to impose a genetic load on insects that vector diseases or are economic pests to reduce th...
Subjects
Medical Subject Headings: genetic structures
free text keywords: Science & Technology, Life Sciences & Biomedicine, Biology, Life Sciences & Biomedicine - Other Topics, Gene drive, Gene editing, Endonucleases, CRISPR-Cas9, Vector control, Pest control, Mosquitoes, HOMING ENDONUCLEASE, ANOPHELES-GAMBIAE, SEX-RATIO, NATURAL-POPULATIONS, MALARIA MOSQUITO, AEDES-AEGYPTI, DYNAMICS, SYSTEM, REQUIREMENTS, ELIMINATION, 06 Biological Sciences, Developmental Biology, Biology (General), QH301-705.5, Review, Genetics, biology.protein, Gene, Genome editing, Genetic load, CRISPR, Population genetics, Population, education.field_of_study, education
Related Organizations
62 references, page 1 of 5

Sinkins, SP, Gould, F. Gene drive systems for insect disease vectors. Nat Rev Genet. 2006; 7 (6): 427-35 [OpenAIRE] [PubMed] [DOI]

Burt, A. Heritable strategies for controlling insect vectors of disease. Philos Trans R Soc B Biol Sci. 2014; 369 (1656): 20130432 [OpenAIRE] [DOI]

3.Esvelt KM, Smidler AL, Catteruccia F, Church GM. Concerning RNA-guided gene drives for the alteration of wild populations. Elife. 2014;3:e03401.

Champer, J, Buchman, A, Akbari, OS. Cheating evolution: engineering gene drives to manipulate the fate of wild populations. Nat Rev Genet. 2016; 17 (3): 146-59 [OpenAIRE] [PubMed] [DOI]

Gantz, VM, Bier, E. The dawn of active genetics. Bioessays. 2016; 38 (1): 50-63 [OpenAIRE] [PubMed] [DOI]

Alphey, L. Can CRISPR-Cas9 gene drives curb malaria?. Nat Biotechnol. 2016; 34 (2): 149-50 [OpenAIRE] [PubMed] [DOI]

Adelman, ZN, Tu, ZJ. Control of mosquito-borne infectious diseases: sex and gene drive. Trends Parasitol. 2016; 32 (3): 219-29 [OpenAIRE] [PubMed] [DOI]

Leftwich, PT, Bolton, M, Chapman, T. Evolutionary biology and genetic techniques for insect control. Evol Appl. 2016; 9 (1): 212-30 [OpenAIRE] [PubMed] [DOI]

Craig, GB, Hickey, WA, van de Hey, RC. An inherited male-producing factor in Aedes aegypti. Science. 1960; 132: 1887-9 [OpenAIRE] [PubMed] [DOI]

Hickey, WA, Craig, GB. Genetic distortion of sex ratio in a mosquito, Aedes aegypti. Genetics. 1966; 53: 1177-96 [OpenAIRE] [PubMed]

Curtis, CF. Possible use of translocations to fix desirable genes in insect pest populations. Nature. 1968; 218: 368-9 [OpenAIRE] [PubMed] [DOI]

Hamilton, WD. Extraordinary sex ratios. Science. 1967; 156: 477-88 [OpenAIRE] [PubMed] [DOI]

Burt, A, Trivers, R. Genes in conflict. 2006

Stoddard, BL. Homing endonuclease structure and function. Q Rev Biophys. 2005; 38 (1): 49-95 [PubMed] [DOI]

Burt, A. Site-specific selfish genes as tools for the control and genetic engineering of natural populations. Proc Biol Sci. 2003; 270 (1518): 921-8 [OpenAIRE] [PubMed] [DOI]

62 references, page 1 of 5
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