publication . Other literature type . Article . 1991

Aminoglycoside resistance and aminoglycoside usage: ten years of experience in one hospital.

D N Gerding; T A Larson; R A Hughes; M Weiler; C Shanholtzer; L R Peterson;
Open Access English
  • Published: 01 Jul 1991
Abstract
For 10 years the 700-bed Minneapolis Veterans Affairs Medical Center has conducted a policy of carefully controlled aminoglycoside usage and monitoring of resistance of over 25,000 aerobic and facultative gram-negative bacillary isolates to the aminoglycosides. On two occasions during the 1980s, our experience of introducing amikacin at a high level of usage was associated with a significant reduction in resistance to gentamicin and tobramycin among gram-negative bacilli. Rapid reintroduction of gentamicin usage in 1982 after the first amikacin period was associated with a significant and rapid increase in gentamicin and tobramycin resistance. However, in 1986, ...
Subjects
free text keywords: Research Article, Pharmacology (medical), Pharmacology, Infectious Diseases, Microbiology, Veterans Affairs, Amikacin, medicine.drug, medicine, Tobramycin, Gentamicin, Aminoglycoside, business.industry, business, Antibiotics, medicine.drug_class, Pseudomonas aeruginosa, medicine.disease_cause
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