publication . Article . Other literature type . 2017

Biology of pancreatic stellate cells-more than just pancreatic cancer.

Ferdek, Pawel E.; Jakubowska, Monika A.;
Open Access English
  • Published: 05 Apr 2017
  • Publisher: Springer
  • Country: United Kingdom
Abstract
Pancreatic stellate cells, normally quiescent, are capable of remarkable transition into their activated myofibroblast-like phenotype. It is now commonly accepted that these cells play a pivotal role in the desmoplastic reaction present in severe pancreatic disorders. In recent years, enormous scientific effort has been devoted to understanding their roles in pancreatic cancer, which continues to remain one of the most deadly diseases. Therefore, it is not surprising that considerably less attention has been given to studying physiological functions of pancreatic stellate cells. Here, we review recent advances not only in the field of pancreatic stellate cell pa...
Subjects
free text keywords: Q1, Invited Review, Pancreatic stellate cells, Fibrosis, Pancreatitis, Pancreatic cancer, Calcium, Myofibroblasts, Clinical Biochemistry, Physiology (medical), Physiology
Related Organizations
119 references, page 1 of 8

1. Andoh A, Takaya H, Saotome T, Shimada M, Hata K, Araki Y, Nakamura F, Shintani Y, Fujiyama Y, Bamba T (2000) Cytokine regulation of chemokine (IL-8, MCP-1, and RANTES) gene expression in human pancreatic periacinar myofibroblasts. Gastroenterology 119:211-219

2. Apte MV, Haber PS, Applegate TL, Norton ID, McCaughan GW, Korsten MA, Pirola RC, Wilson JS (1998) Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut 43:128-133

3. Apte MV, Haber PS, Darby SJ, Rodgers SC, McCaughan GW, Korsten MA, Pirola RC, Wilson JS (1999) Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis. Gut 44:534-541 [OpenAIRE]

4. Apte MV, Phillips PA, Fahmy RG, Darby SJ, Rodgers SC, McCaughan GW, Korsten MA, Pirola RC, Naidoo D, Wilson JS (2000) Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cells. Gastroenterology 118: 780-794 [OpenAIRE]

5. Apte MV, Park S, Phillips PA, Santucci N, Goldstein D, Kumar RK, Ramm GA, Buchler M, Friess H, McCarroll JA, Keogh G, Merrett N, Pirola R, Wilson JS (2004) Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells. Pancreas 29: 179-187

6. Bachem MG, Schneider E, Gross H, Weidenbach H, Schmid RM, Menke A, Siech M, Beger H, Grunert A, Adler G (1998) Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology 115:421-432 [OpenAIRE]

7. Bachem MG, Schmid-Kotsas A, Siech M, Beger HG, Gress TM, Adler G (2004) Pancreatic stellate cells and their role in fibrogenesis. In: Johnson CD, Imrie CW (eds) Pancreatic disease, basic science and clinical management. Springer-Verlag, London, pp 226-239

8. Bachem MG, Schunemann M, Ramadani M, Siech M, Beger H, Buck A, Zhou S, Schmid-Kotsas A, Adler G (2005) Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. Gastroenterology 128:907-921 [OpenAIRE]

9. Barnard JH, Collings JC, Whiting A, Przyborski SA, Marder TB (2009) Synthetic retinoids: structure-activity relationships. Chemistry 15:11430-11442. doi:10.1002/chem.200901952

10. Bertilsson S, Sward P, Kalaitzakis E (2015) Factors that affect disease progression after first attack of acute pancreatitis. Clin Gastroenterol Hepatol 13:1662-1669 . doi:10.1016/j.cgh.2015. 04.012e1663 [OpenAIRE]

11. Blaner WS, Hendriks HF, Brouwer A, de Leeuw AM, Knook DL, Goodman DS (1985) Retinoids, retinoid-binding proteins, and retinyl palmitate hydrolase distributions in different types of rat liver cells. J Lipid Res 26:1241-1251

12. Blomhoff R, Wake K (1991) Perisinusoidal stellate cells of the liver: important roles in retinol metabolism and fibrosis. FASEB J 5:271-277

13. Braganza JM, Lee SH, McCloy RF, McMahon MJ (2011) Chronic pancreatitis. Lancet 377:1184-1197. doi:10.1016/S0140- 6736(10)61852-1

14. Buchholz M, Kestler HA, Holzmann K, Ellenrieder V, Schneiderhan W, Siech M, Adler G, Bachem MG, Gress TM (2005) Transcriptome analysis of human hepatic and pancreatic stellate cells: organ-specific variations of a common transcriptional phenotype. J Mol Med (Berl) 83:795-805. doi:10.1007/ s00109-005-0680-2 [OpenAIRE]

15. Burnstock G, Novak I (2012) Purinergic signalling in the pancreas in health and disease. J Endocrinol 213:123-141. doi:10.1530/ JOE-11-0434

119 references, page 1 of 8
Abstract
Pancreatic stellate cells, normally quiescent, are capable of remarkable transition into their activated myofibroblast-like phenotype. It is now commonly accepted that these cells play a pivotal role in the desmoplastic reaction present in severe pancreatic disorders. In recent years, enormous scientific effort has been devoted to understanding their roles in pancreatic cancer, which continues to remain one of the most deadly diseases. Therefore, it is not surprising that considerably less attention has been given to studying physiological functions of pancreatic stellate cells. Here, we review recent advances not only in the field of pancreatic stellate cell pa...
Subjects
free text keywords: Q1, Invited Review, Pancreatic stellate cells, Fibrosis, Pancreatitis, Pancreatic cancer, Calcium, Myofibroblasts, Clinical Biochemistry, Physiology (medical), Physiology
Related Organizations
119 references, page 1 of 8

1. Andoh A, Takaya H, Saotome T, Shimada M, Hata K, Araki Y, Nakamura F, Shintani Y, Fujiyama Y, Bamba T (2000) Cytokine regulation of chemokine (IL-8, MCP-1, and RANTES) gene expression in human pancreatic periacinar myofibroblasts. Gastroenterology 119:211-219

2. Apte MV, Haber PS, Applegate TL, Norton ID, McCaughan GW, Korsten MA, Pirola RC, Wilson JS (1998) Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut 43:128-133

3. Apte MV, Haber PS, Darby SJ, Rodgers SC, McCaughan GW, Korsten MA, Pirola RC, Wilson JS (1999) Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis. Gut 44:534-541 [OpenAIRE]

4. Apte MV, Phillips PA, Fahmy RG, Darby SJ, Rodgers SC, McCaughan GW, Korsten MA, Pirola RC, Naidoo D, Wilson JS (2000) Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cells. Gastroenterology 118: 780-794 [OpenAIRE]

5. Apte MV, Park S, Phillips PA, Santucci N, Goldstein D, Kumar RK, Ramm GA, Buchler M, Friess H, McCarroll JA, Keogh G, Merrett N, Pirola R, Wilson JS (2004) Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells. Pancreas 29: 179-187

6. Bachem MG, Schneider E, Gross H, Weidenbach H, Schmid RM, Menke A, Siech M, Beger H, Grunert A, Adler G (1998) Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology 115:421-432 [OpenAIRE]

7. Bachem MG, Schmid-Kotsas A, Siech M, Beger HG, Gress TM, Adler G (2004) Pancreatic stellate cells and their role in fibrogenesis. In: Johnson CD, Imrie CW (eds) Pancreatic disease, basic science and clinical management. Springer-Verlag, London, pp 226-239

8. Bachem MG, Schunemann M, Ramadani M, Siech M, Beger H, Buck A, Zhou S, Schmid-Kotsas A, Adler G (2005) Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. Gastroenterology 128:907-921 [OpenAIRE]

9. Barnard JH, Collings JC, Whiting A, Przyborski SA, Marder TB (2009) Synthetic retinoids: structure-activity relationships. Chemistry 15:11430-11442. doi:10.1002/chem.200901952

10. Bertilsson S, Sward P, Kalaitzakis E (2015) Factors that affect disease progression after first attack of acute pancreatitis. Clin Gastroenterol Hepatol 13:1662-1669 . doi:10.1016/j.cgh.2015. 04.012e1663 [OpenAIRE]

11. Blaner WS, Hendriks HF, Brouwer A, de Leeuw AM, Knook DL, Goodman DS (1985) Retinoids, retinoid-binding proteins, and retinyl palmitate hydrolase distributions in different types of rat liver cells. J Lipid Res 26:1241-1251

12. Blomhoff R, Wake K (1991) Perisinusoidal stellate cells of the liver: important roles in retinol metabolism and fibrosis. FASEB J 5:271-277

13. Braganza JM, Lee SH, McCloy RF, McMahon MJ (2011) Chronic pancreatitis. Lancet 377:1184-1197. doi:10.1016/S0140- 6736(10)61852-1

14. Buchholz M, Kestler HA, Holzmann K, Ellenrieder V, Schneiderhan W, Siech M, Adler G, Bachem MG, Gress TM (2005) Transcriptome analysis of human hepatic and pancreatic stellate cells: organ-specific variations of a common transcriptional phenotype. J Mol Med (Berl) 83:795-805. doi:10.1007/ s00109-005-0680-2 [OpenAIRE]

15. Burnstock G, Novak I (2012) Purinergic signalling in the pancreas in health and disease. J Endocrinol 213:123-141. doi:10.1530/ JOE-11-0434

119 references, page 1 of 8
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