publication . Other literature type . Article . 2003

The versatile bacterial type IV secretion systems

Eric Cascales; Peter J. Christie;
Open Access
  • Published: 01 Nov 2003
  • Publisher: Springer Science and Business Media LLC
Abstract
Bacteria use type IV secretion systems for two fundamental objectives related to pathogenesis — genetic exchange and the delivery of effector molecules to eukaryotic target cells. Whereas gene acquisition is an important adaptive mechanism that enables pathogens to cope with a changing environment during invasion of the host, interactions between effector and host molecules can suppress defence mechanisms, facilitate intracellular growth and even induce the synthesis of nutrients that are beneficial to bacterial colonization. Rapid progress has been made towards defining the structures and functions of type IV secretion machines, identifying the effector molecul...
Subjects
free text keywords: General Immunology and Microbiology, Article, Defence mechanisms, Virulence, Effector, Bacterial colonization, Bacteria, biology.organism_classification, biology, Secretion, Cell biology, Gene, Intracellular
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