publication . Article . Report . 2016

Neuroplastic Effects of Transcranial Direct Current Stimulation on Painful Symptoms Reduction in Chronic Hepatitis C: A Phase II Randomized, Double Blind, Sham Controlled Trial

Brietzke, Aline P.; Rozisky, Joanna R.; Dussan-Sarria, Jairo A.; Deitos, Alicia; Laste, Gabriela; Hoppe, Priscila F. T.; Muller, Suzana; Torres, Iraci L. S.; Alvares-da-Silva, Mário R.; de Amorim, Rivadavio F. B.; ...
Open Access
  • Published: 11 Jan 2016 Journal: Frontiers in Neuroscience, volume 9 (eissn: 1662-453X, Copyright policy)
  • Publisher: Frontiers Media SA
Introduction: Pegylated Interferon Alpha (Peg-IFN) in combination with other drugs is the standard treatment for chronic hepatitis C infection (HCV) and is related to severe painful symptoms. The aim of this study was access the efficacy of transcranial direct current stimulation (tDCS) in controlling the painful symptoms related to Peg-IFN side effects. Materials and Methods: In this phase II double-blind trial, twenty eight (n = 28) HCV subjects were randomized to receive either 5 consecutive days of active tDCS (n = 14) or sham (n = 14) during 5 consecutive days with anodal stimulation over the primary motor cortex region using 2 mA for 20 min. The primary ou...
free text keywords: Estimulação transcraniana por corrente contínua, Hepatite C, Randomized controlled trial, law.invention, law, Anesthesia, Analgesic, Standard treatment, Therapeutic effect, Neuroscience, Chronic pain, medicine.disease, medicine, Pegylated interferon, medicine.drug, business.industry, business, Transcranial direct-current stimulation, medicine.medical_treatment, Surgery, medicine.medical_specialty, Visual analogue scale, Pharmacology, Clinical Trial, Hepatitis C, Hepatitis C virus, PEG-IFN, transcranial direct current stimulation, PEG-INF, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
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