publication . Article . 2015

Previously Uncultured Marine Bacteria Linked to Novel Alkaloid Production

Paul R. Jensen; Sang-Jip Nam; Eun Ju Choi; Deanna S. Beatty; William Fenical; Christopher A. Kauffman; Lauren A. Paul;
Open Access
  • Published: 01 Sep 2015 Journal: Chemistry & Biology, volume 22, pages 1,270-1,279 (issn: 1074-5521, Copyright policy)
  • Publisher: Elsevier BV
  • Country: United States
Abstract
SummaryLow-nutrient media and long incubation times facilitated the cultivation of 20 taxonomically diverse Gram-negative marine bacteria within the phyla Bacteroidetes and Proteobacteria. These strains comprise as many as three new families and include members of clades that had only been observed using culture-independent techniques. Chemical studies of the type strains representing two new families within the order Cytophagales led to the isolation of nine new alkaloid secondary metabolites that can be grouped into four distinct structure classes, including azepinones, aziridines, quinolones, and pyrazinones. Several of these compounds possess antibacterial p...
Subjects
free text keywords: Clinical Biochemistry, Molecular Medicine, Biochemistry, Molecular Biology, Pharmacology, Drug Discovery, General Medicine, Alkaloids, Anti-Bacterial Agents, Sequence Analysis, DNA, Phylogeny, Molecular Sequence Data, Aquatic Organisms, Organic Chemistry, Medicinal and Biomolecular Chemistry, Biochemistry and Cell Biology, Phylum, Phylogenetics, Proteobacteria, biology.organism_classification, biology, Natural product, chemistry.chemical_compound, chemistry, Botany, Amino acid, chemistry.chemical_classification, Bacteroidetes, Marine bacteriophage, Clade
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