publication . Article . Other literature type . 2000

Testing Linkage Disequilibrium in Sibships

Siegmund, Kimberly D.; Langholz, Bryan; Kraft, Peter; Thomas, Duncan C.;
Open Access
  • Published: 01 Jul 2000 Journal: The American Journal of Human Genetics, volume 67, pages 244-248 (issn: 0002-9297, Copyright policy)
  • Publisher: Elsevier BV
Abstract
We describe the use of multivariate regression for testing allelic association in the presence of linkage, using marker genotype data from sibships. The test is valid, provided that the correct mean structure is modeled but does not require the correlation structure within families to be specified. The test can be implemented using standard statistical software such as the SAS programming language. In a simulation study, we evaluated this new test in comparison with one from a standard, matched–case-control analysis. First, we noted that the genetic effect needed to be quite extreme before residual familial correlation due to linkage led to false inference using...
Subjects
free text keywords: Genetics(clinical), Genetics, Report
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