publication . Other literature type . Article . 2001

Surgical Management of GH-Secreting Pituitary Adenomas: An Outcome Study Using Modern Remission Criteria

J. Kreutzer; M. L. Vance; M. B. S. Lopes; E. R. Laws;
Open Access
  • Published: 01 Sep 2001
  • Publisher: The Endocrine Society
Abstract
The results of transsphenoidal surgery as initial therapy for GH-secreting pituitary adenomas in 57 acromegalic patients were analyzed retrospectively. Patients with prior surgery or radiation therapy were excluded from the study. Three different criteria were used to define remission: glucose-suppressed (nadir) GH less than 1.0 μg/liter, a normal sex- and age-adjusted IGF-I level, and postoperative random GH levels of 2.5 μg/liter or less. Additionally, we analyzed the neuropathological data, including immunohistochemistry and ultrastructural categorization, and the surgical complications. The short-term remission rate (6-wk postoperative follow-up visit), as d...
Subjects
free text keywords: Clinical Biochemistry, Biochemistry, Endocrinology, Diabetes and Metabolism, Endocrinology, Biochemistry, medical
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