publication . Article . Other literature type . 2008

The link between childhood trauma and depression: insights from HPA axis studies in humans.

Christine Heim; D. Jeffrey Newport; Tanja Mletzko; Andrew H. Miller; Charles B. Nemeroff;
  • Published: 01 Jul 2008
Childhood trauma is a potent risk factor for developing depression in adulthood, particularly in response to additional stress. We here summarize results from a series of clinical studies suggesting that childhood trauma in humans is associated with sensitization of the neuroendocrine stress response, glucocorticoid resistance, increased central corticotropin-releasing factor (CRF) activity, immune activation, and reduced hippocampal volume, closely paralleling several of the neuroendocrine features of depression. Neuroendocrine changes secondary to early-life stress likely reflect risk to develop depression in response to stress, potentially due to failure of a...
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free text keywords: Biological Psychiatry, Endocrinology, Diabetes and Metabolism, Endocrinology, Endocrine and Autonomic Systems, Psychiatry and Mental health, Sensitization, medicine.anatomical_structure, medicine, Pascal (unit), Hypothalamic–pituitary–adrenal axis, Bioinformatics, Risk factor, Clinical care, Adverse outcomes, Psychiatry, medicine.medical_specialty, Immune activation, Differential treatment, Psychology
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