publication . Article . Other literature type . 1997

multiple pathways for the regulation of telomerase activity

Holt, S.E.; Wright, W.E.; Shay, J.W.;
Restricted
  • Published: 01 Apr 1997 Journal: European Journal of Cancer, volume 33, pages 761-766 (issn: 0959-8049, Copyright policy)
  • Publisher: Elsevier BV
Abstract
The ends of vertebrate chromosomes are composed of large tracts of a repeated sequence, TTAGGG, which are known as telomeres. Normal somatic cells progressively lose telomeric repeats with each successive cell division due to incomplete replication. Immortal and cancer cells compensate for telomeric loss by expressing the enzyme telomerase, an RNA-dependent DNA polymerase that maintains telomere length. Telomerase activity has been detected in almost 90% of all human cancers. Telomerase activity is generally absent in normal somatic tissues but is detected in adult testes, activated lymphocytes, and lower levels are expressed in proliferative cells of renewal ti...
Subjects
free text keywords: Cancer Research, Oncology, Immunology, Molecular biology, Cancer cell, Cellular differentiation, Cell biology, Somatic cell, Telomere, Biology, Cell division, Telomerase RNA component, Telomerase, Telomerase reverse transcriptase
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publication . Article . Other literature type . 1997

multiple pathways for the regulation of telomerase activity

Holt, S.E.; Wright, W.E.; Shay, J.W.;