research data . Dataset . 2013

Membrane Environment Imposes Unique Selection Pressures on Transmembrane Domains of G Protein-Coupled Receptors

Lab, Claus Wilke; Spielman, Stephanie J.; Wilke, Claus;
  • Published: 01 Jan 2013
  • Publisher: Figshare
Abstract
<p>G protein-coupled receptors (GPCRs) represent one of the largest families of membrane proteins in eukaryotes. In Metazoa, GPCRs play significant roles in a wide variety of cri6cal physiological func6ons, including percep6on and metabolism, and over 40% of pharmaceu6cals target GPCRs [1]. Despite their clear func6onal importance, few studies have examined their evolu6on, or indeed the evolu6on of membrane proteins, which account for up to 35% of an organism’s proteome. Here, we present a large-scale computa6onal study of the molecular evolu6on of over 350 mammalian GPCRs, including up to 27 species per gene [2]. We calculated an evolu6onary rate, dN/dS, or ω, ...
Subjects
free text keywords: Molecular Biology, Evolutionary Biology, 60102 Bioinformatics, Computational Biology, 2013beacon, protein, evolution
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figshare
Dataset . 2013
Provider: Datacite
figshare
Dataset . 2013
Provider: Datacite
figshare
Dataset . 2013
Provider: figshare
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research data . Dataset . 2013

Membrane Environment Imposes Unique Selection Pressures on Transmembrane Domains of G Protein-Coupled Receptors

Lab, Claus Wilke; Spielman, Stephanie J.; Wilke, Claus;