publication . Article . Other literature type . 2007

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

Burton, Paul R.; Clayton, David G.; Cardon, Lon R.; Craddock, Nick; Deloukas, Panos; Duncanson, Audrey; Kwiatkowski, Dominic P.; McCarthy, Mark I.; Ouwehand, Willem H.; Samani, Nilesh J.; ...
English
  • Published: 07 Jun 2007 Journal: Nature, volume 447, issue 7,145 (issn: 0028-0836, eissn: 1476-4687, Copyright policy)
Abstract
<p>There is increasing evidence that genome-wide association ( GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We describe a joint GWA study ( using the Affymetrix GeneChip 500K Mapping Array Set) undertaken in the British population, which has examined similar to 2,000 individuals for each of 7 major diseases and a shared set of similar to 3,000 controls. Case-control comparisons identified 24 independent association signals at P &lt; 5 X 10(-7): 1 in bipolar disorder, 1 in coronary artery disease, 9 in Crohn's disease, 3 in rheumatoid arthritis, 7 in type 1 diabetes and 3 in type 2 diabetes. On the b...
Subjects
free text keywords: C431 Medical Genetics, Article
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publication . Article . Other literature type . 2007

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

Burton, Paul R.; Clayton, David G.; Cardon, Lon R.; Craddock, Nick; Deloukas, Panos; Duncanson, Audrey; Kwiatkowski, Dominic P.; McCarthy, Mark I.; Ouwehand, Willem H.; Samani, Nilesh J.; ...