publication . Other literature type . Article . 2013

Altered Innate Defenses in the Neonatal Gastrointestinal Tract in Response to Colonization by Neuropathogenic Escherichia coli

George M H Birchenough; Malin E V Johansson; Richard A Stabler; Fatma Dalgakiran; Gunnar C Hansson; Brendan W Wren; J Paul Luzio; Peter W Taylor;
Open Access English
  • Published: 24 Jun 2013
  • Publisher: American Society for Microbiology
Abstract
<jats:title>ABSTRACT</jats:title><jats:p>Two-day-old (P2), but not 9-day-old (P9), rat pups are susceptible to systemic infection following gastrointestinal colonization by<jats:named-content xmlns:xlink="http://www.w3.org/1999/xlink" content-type="genus-species" xlink:type="simple">Escherichia coli</jats:named-content>K1. Age dependency reflects the capacity of colonizing K1 to translocate from gastrointestinal (GI) tract to blood. A complex GI microbiota developed by P2, showed little variation over P2 to P9, and did not prevent stable K1 colonization. Substantial developmental expression was observed over P2 to P9, including upregulation of genes encoding com...
Subjects
free text keywords: Molecular Pathogenesis, Immunology, Microbiology, Parasitology, Infectious Diseases, Chromosomal translocation, Colonization, Gastrointestinal tract, Mucus, Gene, Mucin, Biology, Downregulation and upregulation, Escherichia coli, medicine.disease_cause, medicine
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