publication . Article . Other literature type . 2009

Neonatal Necrotizing Enterocolitis – Inflammation and Intestinal Immaturity

Claud, Erika C.;
  • Published: 01 Sep 2009
Neonatal necrotizing enterocolitis is a devastating inflammatory bowel disease of premature infants. The pathogenesis remains incompletely understood and there is no specific treatment. Efforts are ongoing to understand aspects of intestinal immaturity which contribute to susceptibility to this disease. This review focuses on bacterial colonization patterns, intestinal barrier function, and inflammatory responses of immature enterocytes leading to a unique vulnerability of the preterm gut. In addition the possible therapeutic potential of factors in human milk and probiotic bacteria is discussed.
free text keywords: Immunology, Immunology and Allergy, Pharmacology, General Medicine, Inflammation, medicine.symptom, medicine, Disease, Inflammatory bowel disease, medicine.disease, Probiotic bacteria, Pathogenesis, Neonatal necrotizing enterocolitis, Barrier function, business.industry, business, Article
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