publication . Preprint . 2020

Weight change and the incidence of cardiovascular diseases in adults with normal weight, overweight and obesity without chronic diseases; emulating trials using electronic health records

Katsoulis, Michail; DeStavola, Bianca; Diaz-Ordaz, Karla; Gomes, Manuel; Lai, Alvina; Lagiou, Pagona; Wannamethee, Goya; Tsilidis, Kostas; Lumbers, Tom; Denaxas, Spiros; ...
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  • Published: 18 May 2020
  • Publisher: Cold Spring Harbor Laboratory
Abstract
<jats:p>Background: Cross sectional measures of body mass index (BMI) are associated with cardiovascular disease (CVD) incidence, but less is known about whether weight change affects the risk of CVD. Methods: We estimated the effect of 2 year weight change interventions on 7 year risk of CVD, by emulating hypothetical target trials using electronic health records. We identified 138.567 individuals in England between 1998 and 2016, aged 45-69 years old, free of chronic diseases at baseline. We performed pooled logistic regression, using inverse-probability weighting to adjust for baseline and time-varying variables. Each individual was classified into a weight l...
Funded by
EC| BigData Heart
Project
BigData Heart
Big Data 4 Better Hearts - Sofia ref.: 116074
  • Funder: European Commission (EC)
  • Project Code: 116074
  • Funding stream: H2020 | IMI2-RIA
,
WT| Institutional Strategic Support Fund
Project
  • Funder: Wellcome Trust (WT)
  • Project Code: 204928
  • Funding stream: Cross-Remit
,
WT| Institutional Strategic Support Fund
Project
  • Funder: Wellcome Trust (WT)
  • Project Code: 204841
  • Funding stream: Cross-Remit
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publication . Preprint . 2020

Weight change and the incidence of cardiovascular diseases in adults with normal weight, overweight and obesity without chronic diseases; emulating trials using electronic health records

Katsoulis, Michail; DeStavola, Bianca; Diaz-Ordaz, Karla; Gomes, Manuel; Lai, Alvina; Lagiou, Pagona; Wannamethee, Goya; Tsilidis, Kostas; Lumbers, Tom; Denaxas, Spiros; ...