publication . Article . Other literature type . 2011

The Structure of Genetic Linkage Data: From LIPED to 1M SNPs

Thompson, Elizabeth;
Open Access
  • Published: 01 Jul 2011 Journal: Human Heredity, volume 71, pages 86-96 (issn: 0001-5652, eissn: 1423-0062, Copyright policy)
  • Publisher: S. Karger AG
Abstract
There are three assumptions of independence or conditional independence that underlie linkage likelihood computations on sets of related individuals. The first is the independence of meioses, which gives rise to the conditional independence of haplotypes carried by offspring, given those of their parents. The second derives from the assumption of absence of genetic interference, which gives rise to the conditional independence of inheritance vectors, given the inheritance vector at an intermediate location. The third is the assumption of independence of allelic types, at the population level, both among haplotypes of unrelated individuals and also over the loci ...
Subjects
free text keywords: Genetics(clinical), Genetics, Haplotype, Allele, Population, education.field_of_study, education, Locus (genetics), Genetic linkage, Linkage disequilibrium, Founder effect, Biology, Conditional independence, Paper
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