research data . Dataset . 2019

A rare functional variant of SHARPIN attenuates the inflammatory response and associates with increased risk of late-onset Alzheimer’s disease

Asanomi, Yuya; Shigemizu, Daichi; Miyashita, Akinori; Mitsumori, Risa; Mori, Taiki; Norikazu Hara; Ito, Kaoru; Shumpei Niida; Ikeuchi, Takeshi; Ozaki, Kouichi;
  • Published: 20 Jun 2019
  • Publisher: Figshare
Abstract
Abstract Background Late-onset Alzheimer’s disease (LOAD), the most common form of dementia, results from complicated interactions among multiple environmental and genetic factors. Despite recent advances in genetic analysis of LOAD, more than half of the heritability for the disease remains unclear. Although genetic studies in Caucasians found rare risk variants for LOAD with large effect sizes, these variants are hardly detectable in the Japanese population. Methods To identify rare variants possibly explaining part of the genetic architecture for LOAD in Japanese people, we performed whole-exome sequencing analyses of 202 LOAD individuals without the APOE ε4 ...
Subjects
free text keywords: Medicine, Genetics, FOS: Biological sciences, Neuroscience, Biotechnology, 19999 Mathematical Sciences not elsewhere classified, FOS: Mathematics, 111714 Mental Health, FOS: Health sciences, 110309 Infectious Diseases
Download fromView all 3 versions
figshare
Dataset . 2019
Provider: Datacite
figshare
Dataset . 2019
Provider: Datacite
Abstract
Abstract Background Late-onset Alzheimer’s disease (LOAD), the most common form of dementia, results from complicated interactions among multiple environmental and genetic factors. Despite recent advances in genetic analysis of LOAD, more than half of the heritability for the disease remains unclear. Although genetic studies in Caucasians found rare risk variants for LOAD with large effect sizes, these variants are hardly detectable in the Japanese population. Methods To identify rare variants possibly explaining part of the genetic architecture for LOAD in Japanese people, we performed whole-exome sequencing analyses of 202 LOAD individuals without the APOE ε4 ...
Subjects
free text keywords: Medicine, Genetics, FOS: Biological sciences, Neuroscience, Biotechnology, 19999 Mathematical Sciences not elsewhere classified, FOS: Mathematics, 111714 Mental Health, FOS: Health sciences, 110309 Infectious Diseases
Download fromView all 3 versions
figshare
Dataset . 2019
Provider: Datacite
figshare
Dataset . 2019
Provider: Datacite
Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue