publication . Other literature type . Article . 2017

Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites

Massimo Mangino; Jonas Zierer; Suzanne Brewerton; Michael A. Hicks; Tim D. Spector; Cristina Menni; Hung-Chun Yu; Luke A.D. Miller; J. Craig Venter; Nicholas J. Schork; ...
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  • Published: 06 Mar 2017
  • Publisher: Springer Science and Business Media LLC
Abstract
Amalio Telenti, Craig Venter and colleagues report common, low-frequency and rare variants associated with blood metabolite levels using whole-genome sequencing and comprehensive metabolite profiling in 1,960 individuals. They identify 246 metabolites whose levels are associated with genetic variation at 101 loci.
Subjects
free text keywords: Human blood, Metabolite profiling, Metabolomics, Genome-wide association study, Genetics, Biology, Genetic variation, Metabolite, chemistry.chemical_compound, chemistry, Locus (genetics), Whole genome sequencing
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