publication . Article . Other literature type . 2011

A multiple-template approach to protein threading

Peng, Jian; Xu, Jinbo;
Open Access
  • Published: 04 Apr 2011 Journal: Proteins: Structure, Function, and Bioinformatics, volume 79, pages 1,930-1,939 (issn: 0887-3585, Copyright policy)
  • Publisher: Wiley
Most threading methods predict the structure of a protein using only a single template. Due to the increasing number of solved structures, a protein without solved structure is very likely to have more than one similar template structures. Therefore, a natural question to ask is if we can improve modeling accuracy using multiple templates. This article describes a new multiple-template threading method to answer this question. At the heart of this multiple-template threading method is a novel probabilistic-consistency algorithm that can accurately align a single protein sequence simultaneously to multiple templates. Experimental results indicate that our multipl...
free text keywords: Biochemistry, Molecular Biology, Structural Biology, Sequence alignment, Crystallography, Template method pattern, Protein structure prediction, Structural alignment, Computer science, Threading (manufacturing), Multiple sequence alignment, Template, Algorithm, Threading (protein sequence), Theoretical computer science, Article
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