publication . Article . Other literature type . 2010

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

Clifford Jack; Knopman, Ds; Jagust, Wj; Shaw, Lm; Aisen, Ps; Weiner, Mw; Petersen, Rc; Trojanowski, Jq;
Open Access
  • Published: 01 Jan 2010 Journal: The Lancet Neurology, volume 9, pages 119-128 (issn: 1474-4422, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Summary Currently available evidence strongly supports the position that the initiating event in Alzheimer's disease (AD) is related to abnormal processing of β-amyloid (Aβ) peptide, ultimately leading to formation of Aβ plaques in the brain. This process occurs while individuals are still cognitively normal. Biomarkers of brain β-amyloidosis are reductions in CSF Aβ 42 and increased amyloid PET tracer retention. After a lag period, which varies from patient to patient, neuronal dysfunction and neurodegeneration become the dominant pathological processes. Biomarkers of neuronal injury and neurodegeneration are increased CSF tau and structural MRI measures of cer...
Subjects
free text keywords: Neuroscience, Amyloid, Pathology, medicine.medical_specialty, medicine, Alzheimer's Disease Neuroimaging Initiative, Florbetaben, Pittsburgh compound B, chemistry.chemical_compound, chemistry, Alzheimer's disease, medicine.disease, Neurodegeneration, Alzheimer's disease biomarkers, business.industry, business, Cerebral atrophy
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