publication . Article . Other literature type . 2004

Aquaporin-4 is increased in the sclerotic hippocampus in human temporal lobe epilepsy.

Ole Petter Ottersen; Jung H. Kim; Dennis D. Spencer; Tore Eid; Shrikant Mane; Nihal C. de Lanerolle; Tih-Shih Lee;
  • Published: 26 Oct 2004
The hippocampus of patients with mesial temporal lobe epilepsy is often hardened and shrunken, a condition known as sclerosis. Magnetic resonance imaging reveals an increase in the T2-weighted signal, while diffusion weighted imaging shows a higher apparent diffusion coefficient in sclerotic hippocampi, indicating increased water content. As water transport appears to be coupled to K+ clearance and neuronal excitability [4], the molecular basis of the perturbed water homeostasis in the sclerotic hippocampus was explored. The expression of aquaporin-4 (AQP-4), the predominant water channel in the brain, was studied with quantitative real time PCR analysis, light ...
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free text keywords: Dystrophin, biology.protein, biology, Temporal lobe, Astrocyte, medicine.anatomical_structure, medicine, Hippocampal sclerosis, medicine.disease, Pathology, medicine.medical_specialty, Aquaporin 4, Glial fibrillary acidic protein, Water transport, Hippocampus
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