publication . Other literature type . Article . 2016

Assessment of the genetic variance of late-onset Alzheimer's disease.

Lindsay A. Farrer; Jeffrey Burns; Gyungah Jun; Peter St George-Hyslop; M. Ilyas Kamboh; Kathryn Lunetta; James Leverenz; Chiao-Feng Lin; Alison Goate; Debby Tsuang; ...
Open Access
  • Published: 01 May 2016
  • Publisher: Elsevier BV
AbstractAlzheimer's disease (AD) is a complex genetic disorder with no effective treatments. More than 20 common markers have been identified, which are associated with AD. Recently, several rare variants have been identified in Amyloid Precursor Protein (APP), Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) and Unc-5 Netrin Receptor C (UNC5C) that affect risk for AD. Despite the many successes, the genetic architecture of AD remains unsolved. We used Genome-wide Complex Trait Analysis to (1) estimate phenotypic variance explained by genetics; (2) calculate genetic variance explained by known AD single nucleotide polymorphisms (SNPs); and (3) identify t...
free text keywords: Developmental Biology, Ageing, General Neuroscience, Geriatrics and Gerontology, Clinical Neurology, Alzheimer's disease, Genetics, Genetic variance, Neuroscience(all)
Funded by
  • Funder: Wellcome Trust (WT)
  • Funder: Canadian Institutes of Health Research (CIHR)
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