publication . Preprint . Other literature type . Article . 2017

Genome-wide association analysis of 350,000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema.

Johansson, Åsa; Rask-Andersen, Mathias; Karlsson, Torgny; Ek, Weronica E;
Open Access
  • Published: 29 Sep 2017
  • Publisher: Cold Spring Harbor Laboratory
  • Country: Norway
Abstract
<jats:title>Abstract</jats:title><jats:p>Even though heritability estimates suggest that the risk of asthma, hay fever and eczema is largely due to genetic factors, previous studies have not explained a large part of the genetics behind these diseases. In this GWA study, we include 346,545 Caucasians from the UK Biobank to identify novel loci for asthma, hay fever and eczema. We further investigate if associated lead SNPs have a significantly larger effect for one disease compared to the other diseases, to highlight possible disease specific effects.</jats:p><jats:p>We identified 141 loci, of which 41 are novel, to be associated (P≤3×10<jats:sup>−8</jats:sup>) w...
Subjects
Medical Subject Headings: immune system diseases
free text keywords: Immunology in the medical area, Immunologi inom det medicinska området, Asthma, medicine.disease, medicine, Heritability, Disease, Hay fever, Genetics, Single-nucleotide polymorphism, Genome-wide association study, Biology, Expression quantitative trait loci, SNP, Immunology, Genetics(clinical), Molecular Biology, General Medicine, Biobank, Locus (genetics), Phenotype, Genome-Wide Association Analysis, Association Studies Article
Related Organizations
Funded by
WT
Project
  • Funder: Wellcome Trust (WT)
60 references, page 1 of 4

1.Ober C. and Yao T.C. (2011) The genetics of asthma and allergic disease: a 21st century perspective. Immunol. Rev., 242, 10–30.21682736 [OpenAIRE] [PubMed]

2.Marenholz I., Esparza-Gordillo J., Ruschendorf F., Bauerfeind A., Strachan D.P., Spycher B.D., Baurecht H., Margaritte-Jeannin P., Saaf A., Kerkhof M.et al. (2015) Meta-analysis identifies seven susceptibility loci involved in the atopic march. Nat. Commun., 6, 8804.26542096 [OpenAIRE] [PubMed]

3.Ferreira M.A.R., Matheson M.C., Tang C.S., Granell R., Ang W., Hui J., Kiefer A.K., Duffy D.L., Baltic S., Danoy P.et al. (2014) Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. J. Allergy Clin. Immunol., 133, 1564–1571.2438 8013 [OpenAIRE] [PubMed]

4.Hinds D.A., McMahon G., Kiefer A.K., Do C.B., Eriksson N., Evans D.M., St Pourcain B., Ring S.M., Mountain J.L., Francke U.et al. (2013) A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. Nat. Genet., 45, 907–911.23817569 [OpenAIRE] [PubMed]

5.Portelli M.A., Hodge E. and Sayers I. (2015) Genetic risk factors for the development of allergic disease identified by genome-wide association. Clin. Exp. Allergy, 45, 21–31.24766371 [OpenAIRE] [PubMed]

6.Ferreira M.A., Vonk J.M., Baurecht H., Marenholz I., Tian C., Hoffman J.D., Helmer Q., Tillander A., Ullemar V., Van Dongen J.et al. (2017) Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology. Nat. Genet., 49, 1752–1757.29083406 [OpenAIRE] [PubMed]

7.Demenais F., Margaritte-Jeannin P., Barnes K.C., Cookson W.O.C., Altmüller J., Ang W., Barr R.G., Beaty T.H., Becker A.B., Beilby J.et al. (2018) Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nat. Genet., 50, 42–53.29273806 [PubMed]

8.Waage J., Standl M., Curtin J.A., Jessen L.E., Thorsen J., Tian C., Schoettler N., Flores C., Abdellaoui A., Ahluwalia T.S.et a l. (2018) Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis. Nat. Genet., 50, 1072–1080.30013184 [OpenAIRE] [PubMed]

9.Zhu Z., Lee P.H., Chaffin M.D., Chung W., Loh P.R., Lu Q., Christiani D.C. and Liang L. (2018) A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases. Nat. Genet., 50, 857–864.29785011 [OpenAIRE] [PubMed]

10.Ullemar V., Magnusson P.K.E., Lundholm C., Zettergren A., Melén E., Lichtenstein P. and Almqvist C. (2016) Heritability and confirmation of genetic association studies for childhood asthma in twins. Allergy Eur. J. Allergy Clin. Immunol., 71, 230–238.

11.Fagnani C., Annesi-Maesano I., Brescianini S., D'Ippolito C., Medda E., NisticòL., Patriarca V., Rotondi D., Toccaceli V. and Stazi M.A. (2008) Heritability and shared genetic effects of asthma and hay fever: an Italian study of young twins. Twin Res. Hum. Genet., 11, 121–131.18361712 [OpenAIRE] [PubMed]

12.Bataille V., Lens M. and Spector T.D. (2012) The use of the twin model to investigate the genetics and epigenetics of skin diseases with genomic, transcriptomic and methylation data. J. Eur. Acad. Dermatol. Venereol., 26, 1067–1073.22243446 [PubMed]

13.Moffatt M.F., Gut I.G., Demenais F., Strachan D.P., Bouzigon E., Heath S., von Mutius E., Farrall M., Lathrop M. and Cookson W.O.C.M. (2010) A large-scale, consortium-based genomewide association study of asthma. N. Engl. J. Med., 363, 1211–1221.20860503 [OpenAIRE] [PubMed]

14.Yang J., Ferreira T., Morris A.P., Medland S.E., Madden P.A.F., Heath A.C., Martin N.G., Montgomery G.W., Weedon M.N., Loos R.J.et al. (2012) Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat. Genet., 44, 369–375.22426310 [OpenAIRE] [PubMed]

15.Hirota T., Takahashi A., Kubo M., Tsunoda T., Tomita K., Sakashita M., Yamada T., Fujieda S., Tanaka S., Doi S.et al. (2012) Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. Nat. Genet., 44, 1222–1226.23042114 [PubMed]

60 references, page 1 of 4
Abstract
<jats:title>Abstract</jats:title><jats:p>Even though heritability estimates suggest that the risk of asthma, hay fever and eczema is largely due to genetic factors, previous studies have not explained a large part of the genetics behind these diseases. In this GWA study, we include 346,545 Caucasians from the UK Biobank to identify novel loci for asthma, hay fever and eczema. We further investigate if associated lead SNPs have a significantly larger effect for one disease compared to the other diseases, to highlight possible disease specific effects.</jats:p><jats:p>We identified 141 loci, of which 41 are novel, to be associated (P≤3×10<jats:sup>−8</jats:sup>) w...
Subjects
Medical Subject Headings: immune system diseases
free text keywords: Immunology in the medical area, Immunologi inom det medicinska området, Asthma, medicine.disease, medicine, Heritability, Disease, Hay fever, Genetics, Single-nucleotide polymorphism, Genome-wide association study, Biology, Expression quantitative trait loci, SNP, Immunology, Genetics(clinical), Molecular Biology, General Medicine, Biobank, Locus (genetics), Phenotype, Genome-Wide Association Analysis, Association Studies Article
Related Organizations
Funded by
WT
Project
  • Funder: Wellcome Trust (WT)
60 references, page 1 of 4

1.Ober C. and Yao T.C. (2011) The genetics of asthma and allergic disease: a 21st century perspective. Immunol. Rev., 242, 10–30.21682736 [OpenAIRE] [PubMed]

2.Marenholz I., Esparza-Gordillo J., Ruschendorf F., Bauerfeind A., Strachan D.P., Spycher B.D., Baurecht H., Margaritte-Jeannin P., Saaf A., Kerkhof M.et al. (2015) Meta-analysis identifies seven susceptibility loci involved in the atopic march. Nat. Commun., 6, 8804.26542096 [OpenAIRE] [PubMed]

3.Ferreira M.A.R., Matheson M.C., Tang C.S., Granell R., Ang W., Hui J., Kiefer A.K., Duffy D.L., Baltic S., Danoy P.et al. (2014) Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. J. Allergy Clin. Immunol., 133, 1564–1571.2438 8013 [OpenAIRE] [PubMed]

4.Hinds D.A., McMahon G., Kiefer A.K., Do C.B., Eriksson N., Evans D.M., St Pourcain B., Ring S.M., Mountain J.L., Francke U.et al. (2013) A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. Nat. Genet., 45, 907–911.23817569 [OpenAIRE] [PubMed]

5.Portelli M.A., Hodge E. and Sayers I. (2015) Genetic risk factors for the development of allergic disease identified by genome-wide association. Clin. Exp. Allergy, 45, 21–31.24766371 [OpenAIRE] [PubMed]

6.Ferreira M.A., Vonk J.M., Baurecht H., Marenholz I., Tian C., Hoffman J.D., Helmer Q., Tillander A., Ullemar V., Van Dongen J.et al. (2017) Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology. Nat. Genet., 49, 1752–1757.29083406 [OpenAIRE] [PubMed]

7.Demenais F., Margaritte-Jeannin P., Barnes K.C., Cookson W.O.C., Altmüller J., Ang W., Barr R.G., Beaty T.H., Becker A.B., Beilby J.et al. (2018) Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nat. Genet., 50, 42–53.29273806 [PubMed]

8.Waage J., Standl M., Curtin J.A., Jessen L.E., Thorsen J., Tian C., Schoettler N., Flores C., Abdellaoui A., Ahluwalia T.S.et a l. (2018) Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis. Nat. Genet., 50, 1072–1080.30013184 [OpenAIRE] [PubMed]

9.Zhu Z., Lee P.H., Chaffin M.D., Chung W., Loh P.R., Lu Q., Christiani D.C. and Liang L. (2018) A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases. Nat. Genet., 50, 857–864.29785011 [OpenAIRE] [PubMed]

10.Ullemar V., Magnusson P.K.E., Lundholm C., Zettergren A., Melén E., Lichtenstein P. and Almqvist C. (2016) Heritability and confirmation of genetic association studies for childhood asthma in twins. Allergy Eur. J. Allergy Clin. Immunol., 71, 230–238.

11.Fagnani C., Annesi-Maesano I., Brescianini S., D'Ippolito C., Medda E., NisticòL., Patriarca V., Rotondi D., Toccaceli V. and Stazi M.A. (2008) Heritability and shared genetic effects of asthma and hay fever: an Italian study of young twins. Twin Res. Hum. Genet., 11, 121–131.18361712 [OpenAIRE] [PubMed]

12.Bataille V., Lens M. and Spector T.D. (2012) The use of the twin model to investigate the genetics and epigenetics of skin diseases with genomic, transcriptomic and methylation data. J. Eur. Acad. Dermatol. Venereol., 26, 1067–1073.22243446 [PubMed]

13.Moffatt M.F., Gut I.G., Demenais F., Strachan D.P., Bouzigon E., Heath S., von Mutius E., Farrall M., Lathrop M. and Cookson W.O.C.M. (2010) A large-scale, consortium-based genomewide association study of asthma. N. Engl. J. Med., 363, 1211–1221.20860503 [OpenAIRE] [PubMed]

14.Yang J., Ferreira T., Morris A.P., Medland S.E., Madden P.A.F., Heath A.C., Martin N.G., Montgomery G.W., Weedon M.N., Loos R.J.et al. (2012) Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat. Genet., 44, 369–375.22426310 [OpenAIRE] [PubMed]

15.Hirota T., Takahashi A., Kubo M., Tsunoda T., Tomita K., Sakashita M., Yamada T., Fujieda S., Tanaka S., Doi S.et al. (2012) Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. Nat. Genet., 44, 1222–1226.23042114 [PubMed]

60 references, page 1 of 4
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