publication . Article . Other literature type . 1979

Glucose Clamp Technique: A Method for Quantifying Insulin Secretion and Resistance

DeFronzo, R A; Tobin, J D; Andres, R;
  • Published: 01 Sep 1979
Abstract
<jats:p> Methods for the quantification of beta-cell sensitivity to glucose (hyperglycemic clamp technique) and of tissue sensitivity to insulin (euglycemic insulin clamp technique) are described. Hyperglycemic clamp technique. The plasma glucose concentration is acutely raised to 125 mg/dl above basal levels by a priming infusion of glucose. The desired hyperglycemic plateau is subsequently maintained by adjustment of a variable glucose infusion, based on the negative feedback principle. Because the plasma glucose concentration is held constant, the glucose infusion rate is an index of glucose metabolism. Under these conditions of constant hyperglycemia, the pl...
Subjects
free text keywords: Physiology (medical), Physiology, Endocrinology, Diabetes and Metabolism, Glucose uptake, Diabetes mellitus, medicine.disease, medicine, Insulin, medicine.medical_treatment, Endocrinology, medicine.medical_specialty, Glucose clamp technique, Internal medicine, Hyperglycemic agent, Quantitative insulin sensitivity check index, Clamp, Carbohydrate metabolism, Biology
Related Organizations
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . Other literature type . 1979

Glucose Clamp Technique: A Method for Quantifying Insulin Secretion and Resistance

DeFronzo, R A; Tobin, J D; Andres, R;