publication . Other literature type . Article . 2019

Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology.

Ibrahima Diouf; Ashley Bush; Scott Ayton;
Open Access
  • Published: 18 Feb 2019
  • Publisher: Springer Science and Business Media LLC
Abstract
: Cortical iron has been shown to be elevated in Alzheimer's disease (AD), but the impact of the directly measured iron on the clinical syndrome has not been assessed. We investigated the association between post-mortem iron levels with the clinical and pathological diagnosis of AD, its severity, and the rate of cognitive decline in the 12 years prior to death in subjects from the Memory and Aging Project (n = 209). Iron was elevated (β [SE] = 9.7 [2.6]; P = 3.0 × 10-4) in the inferior temporal cortex only in subjects who were diagnosed with clinical AD during life and had a diagnosis of AD confirmed post-mortem by standardized criteria. Although iron was weakly...
Subjects
free text keywords: Article, Molecular Biology, Cellular and Molecular Neuroscience, Psychiatry and Mental health
Funded by
NIH| Neuropathologic-Epidemiological Study of Metallomics and Alzheimer's Disease
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1RF1AG054057-01
  • Funding stream: NATIONAL INSTITUTE ON AGING
,
NIH| Epidemiologic Study of Neural Reserve and Neurobiology of Aging
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 3R01AG017917-11A1S1
  • Funding stream: NATIONAL INSTITUTE ON AGING
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