publication . Article . Other literature type . 2015

Immune Regulation of Metabolic Homeostasis in Health and Disease

Brestoff, Jonathan R.; Artis, David;
Open Access
  • Published: 01 Mar 2015 Journal: Cell, volume 161, pages 146-160 (issn: 0092-8674, Copyright policy)
  • Publisher: Elsevier BV
Obesity is an increasingly prevalent disease worldwide. While genetic and environmental factors are known to regulate the development of obesity and associated metabolic diseases, emerging studies indicate that innate and adaptive immune cell responses in adipose tissue have critical roles in the regulation of metabolic homeostasis. In the lean state, type 2 cytokine-associated immune cell responses predominate in white adipose tissue and protect against weight gain and insulin resistance through direct effects on adipocytes and elicitation of beige adipose. In obesity, these metabolically beneficial immune pathways become dysregulated, and adipocytes and other ...
free text keywords: General Biochemistry, Genetics and Molecular Biology, Homeostasis, Immunology, Disease, Immune system, White adipose tissue, Inflammation, medicine.symptom, medicine, Adipose tissue, Insulin resistance, medicine.disease, Biology, Adipocyte, chemistry.chemical_compound, chemistry, Article, Biochemistry, Genetics and Molecular Biology(all)
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