publication . Article . Other literature type . 2017

Early and late change on the preclinical Alzheimer's cognitive composite in clinically normal older individuals with elevated amyloid-β

Mormino, Elizabeth C.; Papp, Kathryn V.; Rentz, Dorene M.; Donohue, Michael C.; Amariglio, Rebecca; Quiroz, Yakeel T.; Chhatwal, Jasmeer; Marshall, Gad A.; Donovan, Nancy; Jackson, Jonathan; ...
Open Access
  • Published: 27 Feb 2017 Journal: Alzheimer's & Dementia, volume 13, pages 1,004-1,012 (issn: 1552-5260, Copyright policy)
  • Publisher: Wiley
Abstract
Abstract Introduction Sensitive detection of cognitive decline over the course of preclinical Alzheimer's disease is critical as the field moves toward secondary prevention trials. Methods We examined amyloid β (Aβ)-related change in several variations of the preclinical Alzheimer cognitive composite (PACC) and each individual PACC component in clinically normal (CN) older participants in the Harvard Aging Brain Study. We then examined the PACC variations in the Alzheimer's Disease Cooperative Study Prevention Instrument Study as a replication cohort. Results Aβ+ CN individuals demonstrated longitudinal decline on all individual PACC components and all PACC vari...
Subjects
free text keywords: Health Policy, Developmental Neuroscience, Epidemiology, Cellular and Molecular Neuroscience, Geriatrics and Gerontology, Psychiatry and Mental health, Clinical Neurology, Cognition, Psychiatry, medicine.medical_specialty, medicine, Oncology, Cohort, Psychology, Pathology, Clinical Dementia Rating, Disease, Internal medicine, Amyloid, Aging brain, Diabetes mellitus, medicine.disease, Cognitive decline, Article
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