publication . Article . Other literature type . 2006

The Role of Nitric Oxide and GluR1 in Presynaptic and Postsynaptic Components of Neocortical Potentiation

Neil Hardingham; Kevin Fox;
Open Access English
  • Published: 12 Jul 2006
  • Country: United Kingdom
Abstract
In this study, we investigated the mechanisms underlying synaptic plasticity at the layer IV to II/III pathway in barrel cortex of mice aged 6–13 weeks. This pathway is one of the likely candidates for expression of experience-dependent plasticity in the barrel cortex and may serve as a model for other IV to II/III synapses in the neocortex. We found that postsynaptic autocamtide-2-inhibitory peptide is sufficient to block long-term potentiation (LTP) (IC 50 of 500 nm), implicating postsynaptic calcium/calmodulin-dependent kinase II in LTP induction. AMPA receptor subunit 1 (GluR1) knock-out mice also showed LTP in this pathway, but potentiation was predominantl...
Subjects
Medical Subject Headings: nervous systemmusculoskeletal, neural, and ocular physiology
free text keywords: Articles, General Neuroscience
Related Organizations
50 references, page 1 of 4

Abbott LF, Regehr WG (2004) Synaptic computation. Nature 431:796 - 803.

Allen PB, Hvalby O, Jensen V, Errington ML, Ramsay M, Chaudhry FA, Bliss TV, Storm-Mathisen J, Morris RG, Andersen P, Greengard P (2000) Protein phosphatase-1 regulation in the induction of long-term potentiation: heterogeneous molecular mechanisms. J Neurosci 20:3537-3543.

Barria A, Muller D, Derkach V, Griffith LC, Soderling TR (1997) Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation. Science 276:2042-2045. [OpenAIRE]

Bredt DS, Ferris CD, Snyder SH (1992) Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites. J Biol Chem 267:10976 -10981.

Brenman JE, Chao DS, Gee SH, McGee AW, Craven SE, Santillano DR, Wu Z, Huang F, Xia H, Peters MF, Froehner SC, Bredt DS (1996) Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains. Cell 84:757-767. [OpenAIRE]

Buonomano DV (1999) Distinct functional types of associative long-term potentiation in neocortical and hippocampal pyramidal neurons. J Neurosci 19:6748 - 6754. [OpenAIRE]

Buonomano DV, Merzenich MM (1998) Cortical plasticity: from synapses to maps. Annu Rev Neurosci 21:149 -186. [OpenAIRE]

Busconi L, Michel T (1993) Endothelial nitric oxide synthase. N-terminal myristoylation determines subcellular localization. J Biol Chem 268:8410 - 8413.

Carpenter GA, Milenova BL (2002) Redistribution of synaptic efficacy supports stable pattern learning in neural networks. Neural Comput 14:873- 888. [OpenAIRE]

Celikel T, Szostak VA, Feldman DE (2004) Modulation of spike timing by sensory deprivation during induction of cortical map plasticity. Nat Neurosci 7:534 -541. [OpenAIRE]

Feldman DE (2000) Timing-based LTP and LTD at vertical inputs to layer II/III pyramidal cells in rat barrel cortex. Neuron 27:45-56.

Feldmeyer D, Lubke J, Silver RA, Sakmann B (2002) Synaptic connections between layer 4 spiny neurone-layer 2/3 pyramidal cell pairs in juvenile rat barrel cortex: physiology and anatomy of interlaminar signalling within a cortical column. J Physiol (Lond) 538:803- 822. [OpenAIRE]

Finnerty GT, Roberts LS, Connors BW (1999) Sensory experience modifies the short-term dynamics of neocortical synapses. Nature 400:367-371.

Fox K (1994) The cortical component of experience-dependent synaptic plasticity in the rat barrel cortex. J Neurosci 14:7665-7679.

Fox K (2002) Anatomical pathways and molecular mechanisms for plasticity in the barrel cortex. Neuroscience 111:799 - 814.

50 references, page 1 of 4
Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue