publication . Article . Other literature type . 2011

Gene expression regulation in trypanosomatids.

Alejandro Cassola;
Open Access
  • Published: 24 Oct 2011 Journal: Essays in Biochemistry, volume 51, pages 31-46 (issn: 0071-1365, eissn: 1744-1358, Copyright policy)
  • Publisher: Portland Press Ltd.
Abstract
<jats:p>Trypanosomatids are protozoan micro-organisms that cause serious health problems in humans and domestic animals. In addition to their medical relevance, these pathogens have novel biological structures and processes. From nuclear DNA transcription to mRNA translation, trypanosomes use unusual mechanisms to control gene expression. For example, transcription by RNAPII (RNA polymerase II) is polycistronic, and only a few transcription initiation sites have been identified so far. The sequences present in the polycistronic units code for proteins having unrelated functions, that is, not involved in a similar metabolic pathway. Owing to these biological cons...
Subjects
Medical Subject Headings: parasitic diseases
free text keywords: Biochemistry, Molecular Biology
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