publication . Article . Other literature type . 2018

Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling

Kyle S. McCommis; Zhouji Chen; Xiaorong Fu; William G. McDonald; Jerry R. Colca; Rolf F. Kletzien; Shawn C. Burgess; Brian N. Finck;
Open Access
  • Published: 02 Dec 2018 Journal: Cell Metabolism, volume 22, issue 4, pages 682-694 (issn: 1550-4131, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Pyruvate transport across the inner mitochondrial membrane is believed to be a prerequisite step for gluconeogenesis in hepatocytes, which is important for maintenance of normoglycemia during prolonged food deprivation, but also contributes to hyperglycemia in diabetes. To determine the requirement for mitochondrial pyruvate import in gluconeogenesis, mice with liver-specific deletion of mitochondrial pyruvate carrier 2 (LS-Mpc2−/−) were generated. Loss of MPC2 impaired, but did not completely abolish, hepatocyte pyruvate metabolism, labelled pyruvate conversion to TCA cycle intermediates and glucose, and glucose production from pyruvate. Unbiased metabolomic an...
Subjects
free text keywords: Cell Biology, Physiology, Molecular Biology, Article, Pyruvate dehydrogenase kinase, Mitochondrial pyruvate carrier 2, Internal medicine, medicine.medical_specialty, medicine, Pyruvate decarboxylation, Gluconeogenesis, Pyruvic acid, chemistry.chemical_compound, chemistry, Endocrinology, Pyruvate dehydrogenase complex, Biology, Biochemistry, Pyruvate transport, Pyruvate carboxylase
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publication . Article . Other literature type . 2018

Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling

Kyle S. McCommis; Zhouji Chen; Xiaorong Fu; William G. McDonald; Jerry R. Colca; Rolf F. Kletzien; Shawn C. Burgess; Brian N. Finck;