publication . Other literature type . Article . 2007

Atrophy Rates Accelerate in Amnestic Mild Cognitive Impairment

Clifford Jack; Weigand, Sd; Shiung, Mm; Przybelski, Sa; O Brien, Pc; Gunter, Jl; Knopman, Ds; Boeve, Bf; Smith, Ge; Petersen, Rc;
Open Access English
  • Published: 21 Nov 2007
Abstract
Background: We tested if rates of brain atrophy accelerate in individuals with amnestic mild cognitive impairment (aMCI) as they progress to typical late onset Alzheimer disease (AD). We included comparisons to subjects with aMCI who did not progress (labeled aMCI-S) and also to cognitively normal elderly subjects (CN). Methods: We studied 46 subjects with aMCI who progressed to AD (labeled aMCI-P), 46 CN, and 23 aMCI-S. All subjects must have had three or more serial MRI scans. Rates of brain shrinkage and ventricular expansion were measured across all available serial MRI scans in each subject. Change in volumes relative to the point at which subjects progress...
Subjects
Medical Subject Headings: mental disordersbehavioral disciplines and activities
free text keywords: Article, Clinical Neurology
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Europe PubMed Central
Other literature type . 2007
Neurology
Article
Provider: UnpayWall
Neurology
Article . 2007
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