research data . Dataset . 2019

Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of genetic risk factors

Acker, Zoë Van; Bretou, Marine; Annaert, Wim;
  • Published: 04 Jun 2019
  • Publisher: Figshare
Abstract
Abstract Increasing evidence supports that cellular dysregulations in the degradative routes contribute to the initiation and progression of neurodegenerative diseases, including Alzheimer’s disease. Autophagy and endolysosomal homeostasis need to be maintained throughout life as they are major cellular mechanisms involved in both the production of toxic amyloid peptides and the clearance of misfolded or aggregated proteins. As such, alterations in endolysosomal and autophagic flux, as a measure of degradation activity in these routes or compartments, may directly impact as well on disease-related mechanisms such as amyloid-β clearance through the blood-brain-ba...
Subjects
free text keywords: Biophysics, Biochemistry, Cell Biology, Genetics, FOS: Biological sciences, Molecular Biology, Neuroscience, Physiology, Pharmacology, 69999 Biological Sciences not elsewhere classified, Cancer, Science Policy, 111714 Mental Health, FOS: Health sciences, Computational Biology
Communities
Science and Innovation Policy Studies
Download fromView all 3 versions
figshare
Dataset . 2019
Provider: Datacite
figshare
Dataset . 2019
Provider: Datacite
Abstract
Abstract Increasing evidence supports that cellular dysregulations in the degradative routes contribute to the initiation and progression of neurodegenerative diseases, including Alzheimer’s disease. Autophagy and endolysosomal homeostasis need to be maintained throughout life as they are major cellular mechanisms involved in both the production of toxic amyloid peptides and the clearance of misfolded or aggregated proteins. As such, alterations in endolysosomal and autophagic flux, as a measure of degradation activity in these routes or compartments, may directly impact as well on disease-related mechanisms such as amyloid-β clearance through the blood-brain-ba...
Subjects
free text keywords: Biophysics, Biochemistry, Cell Biology, Genetics, FOS: Biological sciences, Molecular Biology, Neuroscience, Physiology, Pharmacology, 69999 Biological Sciences not elsewhere classified, Cancer, Science Policy, 111714 Mental Health, FOS: Health sciences, Computational Biology
Communities
Science and Innovation Policy Studies
Download fromView all 3 versions
figshare
Dataset . 2019
Provider: Datacite
figshare
Dataset . 2019
Provider: Datacite
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