publication . Doctoral thesis . Other literature type . Article . 2016

Obesity accelerates T cell senescence in murine visceral adipose tissue(要約)

Kohsuke Shirakawa; Xiaoxiang Yan; Ken Shinmura; Jin Endo; Masaharu Kataoka; Yoshinori Katsumata; Tsunehisa Yamamoto; Atsushi Anzai; Sarasa Isobe; Naohiro Yoshida; ...
Open Access Japanese
  • Published: 07 Nov 2016
  • Publisher: 慶應義塾大学大学院医学研究科
Abstract
Abstract Chronic inflammation in visceral adipose tissue (VAT) precipitates the development of cardiometabolic disorders. Although changes in T cell function associated with visceral obesity are thought to affect chronic VAT inflammation, the specific features of these changes remain elusive. Here, we have determined that a high-fat diet (HFD) caused a preferential increase and accumulation of CD44hiCD62LloCD4+ T cells that constitutively express PD-1 and CD153 in a B cell-dependent manner in VAT. These cells possessed characteristics of cellular senescence and showed a strong activation of Spp1 (encoding osteopontin [OPN]) in VAT. Upon T cell receptor stimulati...
Subjects
Medical Subject Headings: nutritional and metabolic diseases
free text keywords: Research Article, Internal medicine, medicine.medical_specialty, medicine, Adoptive cell transfer, business.industry, business, Osteopontin, biology.protein, biology, Biochemistry, Endocrinology, Adipose tissue, Immune system, Population, education.field_of_study, education, T cell, medicine.anatomical_structure, Adipose tissue macrophages, Inflammation, medicine.symptom
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Doctoral thesis
Provider: JAIRO
JAIRO
Doctoral thesis
Provider: JAIRO
JAIRO
Doctoral thesis
Provider: JAIRO
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Other literature type . 2016
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