publication . Article . Other literature type . 2015

Methodological ReviewAn overview of bioinformatics tools for epitope prediction: Implications on vaccine development

Ruth Elena Soria-Guerra; Ricardo Nieto-Gómez; Dania O. Govea-Alonso; Sergio Rosales-Mendoza;
Open Access
  • Published: 01 Feb 2015 Journal: Journal of Biomedical Informatics, volume 53, pages 405-414 (issn: 1532-0464, Copyright policy)
  • Publisher: Elsevier BV
Abstract
AbstractExploitation of recombinant DNA and sequencing technologies has led to a new concept in vaccination in which isolated epitopes, capable of stimulating a specific immune response, have been identified and used to achieve advanced vaccine formulations; replacing those constituted by whole pathogen-formulations. In this context, bioinformatics approaches play a critical role on analyzing multiple genomes to select the protective epitopes in silico. It is conceived that cocktails of defined epitopes or chimeric protein arrangements, including the target epitopes, may provide a rationale design capable to elicit convenient humoral or cellular immune responses...
Subjects
free text keywords: Health Informatics, Computer Science Applications, Antigenic determinants, Databases, Hypervariable pathogens, Immunological software, Immunoprotection, Bioinformatics, Immune system, Acquired immune system, In silico, Vaccination, Major histocompatibility complex, biology.protein, biology, Genome, Computer science, Human leukocyte antigen, Epitope
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