publication . Article . Other literature type . 2019

Association of Cerebrospinal Fluid Neurofilament Light Protein With Risk of Mild Cognitive Impairment Among Individuals Without Cognitive Impairment

Kern, Silke; Syrjanen, Jeremy A.; Blennow, Kaj; Zetterberg, Henrik; Skoog, Ingmar; Waern, Margda; Hagen, Clinton E.; van Harten, Argonde C.; Knopman, David S.; Jack, Clifford R.; ...
Open Access
  • Published: 01 Feb 2019 Journal: JAMA Neurology, volume 76, page 187 (issn: 2168-6149, Copyright policy)
  • Publisher: American Medical Association (AMA)
  • Country: Netherlands
Abstract
Importance Accumulating data suggest that elevated cerebrospinal fluid (CSF) neurofilament light (NfL) and neurogranin (Ng) levels are associated with cognitive decline and may be useful markers of neurodegeneration. However, to our knowledge, previous studies have not assessed these CSF markers in the community, evaluated them with regards to risk of mild cognitive impairment (MCI), or compared their prognostic value with CSF total tau (T-tau) or phosphorylated tau (P-tau). Objective To determine (1) whether CSF NfL and Ng levels were associated with risk of MCI, (2) the effect size of these markers compared with CSF T-tau or P-tau for risk of MCI, and (3) whet...
Subjects
Medical Subject Headings: mental disorders
free text keywords: Risk factor, Cerebrospinal fluid, Quartile, Anesthesia, Cognitive decline, Oncology, medicine.medical_specialty, medicine, Proportional hazards model, Internal medicine, business.industry, business, Hazard ratio, Population, education.field_of_study, education, Interquartile range, Original Investigation
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