publication . Other literature type . Article . 2020

Plasmid-linked Resistance to Inorganic Salts in Staphylococcus aureus

Richard P. Novick; Christine Roth;
Open Access
  • Published: 05 Jan 2020
  • Publisher: American Society for Microbiology
Abstract
The penicillinase plasmids, a series of extrachromosomal resistance factors in Staphylococcus aureus, were found to carry determinants of resistance to a series of inorganic ions as well as resistance to penicillin and, in some cases, erythromycin. Most of the ions involved were inhibitory but not lethal to the bacteria; the resistance markers conferred an increase in resistance by comparison with susceptible organisms of between 3- and 100-fold, depending on the ion involved. Separate genetic loci for resistance to arsenate, arsenite, lead, cadmium, mercuric, and bismuth ions were demonstrated. Resistance to antimony and resistance to zinc were also found but w...
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free text keywords: Molecular Biology, Microbiology, Genetics and Molecular Biology, Inorganic ions, Penicillin, medicine.drug, medicine, Bacteria, biology.organism_classification, biology, Staphylococcus, medicine.disease_cause, Staphylococcus aureus, Plasmid, Extrachromosomal DNA, Arsenite, chemistry.chemical_compound, chemistry
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