publication . Other literature type . Article . 2011

Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease

Bateman, Randall J; Aisen, Paul S; De Strooper, Bart; Fox, Nick C; Lemere, Cynthia A; Ringman, John M; Salloway, Stephen; Sperling, Reisa A; Windisch, Manfred; Xiong, Chengjie;
  • Published: 01 Jan 2011
  • Publisher: Springer Science and Business Media LLC
  • Country: Netherlands
Abstract
Autosomal-dominant Alzheimer's disease has provided significant understanding of the pathophysiology of Alzheimer's disease. The present review summarizes clinical, pathological, imaging, biochemical, and molecular studies of autosomal-dominant Alzheimer's disease, highlighting the similarities and differences between the dominantly inherited form of Alzheimer's disease and the more common sporadic form of Alzheimer's disease. Current developments in autosomal-dominant Alzheimer's disease are presented, including the international Dominantly Inherited Alzheimer Network and this network's initiative for clinical trials. Clinical trials in autosomal-dominant Alzhe...
Subjects
free text keywords: Cognitive Neuroscience, Neurology, Clinical Neurology, medicine.medical_specialty, medicine, Biochemistry of Alzheimer's disease, Neuroscience, Amyloid precursor protein, biology.protein, biology, Dominance (genetics), Cognitive decline, Disease, Pathology, Clinical trial, Gamma secretase, business.industry, business, Review
Funded by
NIH| DIAN Genetics Core
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5U19AG032438-03
  • Funding stream: NATIONAL INSTITUTE ON AGING
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publication . Other literature type . Article . 2011

Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease

Bateman, Randall J; Aisen, Paul S; De Strooper, Bart; Fox, Nick C; Lemere, Cynthia A; Ringman, John M; Salloway, Stephen; Sperling, Reisa A; Windisch, Manfred; Xiong, Chengjie;