publication . Article . Other literature type . 2004

Potent block of Cx36 and Cx50 gap junction channels by mefloquine

Meg A Younger; Barry W. Connors; Matthew G. Hopperstad; Scott J. Cruikshank; Miduturu Srinivas; David C. Spray;
Open Access
  • Published: 05 Aug 2004 Journal: Proceedings of the National Academy of Sciences, volume 101, pages 12,364-12,369 (issn: 0027-8424, eissn: 1091-6490, Copyright policy)
  • Publisher: Proceedings of the National Academy of Sciences
Recently, great interest has been shown in understanding the functional roles of specific gap junction proteins (connexins) in brain, lens, retina, and elsewhere. Some progress has been made by studying knockout mice with targeted connexin deletions. For example, such studies have implicated the gap junction protein Cx36 in synchronizing rhythmic activity of neurons in several brain regions. Although knockout strategies are informative, they can be problematic, because compensatory changes sometimes occur during development. Therefore, it would be extremely useful to have pharmacological agents that block specific connexins, without major effects on other gap ju...
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Medical Subject Headings: sense organs
free text keywords: Biological Sciences, Postsynaptic potential, Neocortex, medicine.anatomical_structure, medicine, Pharmacology, Excitatory postsynaptic potential, Gap junction, Biophysics, Connexin, Inhibitory postsynaptic potential, Membrane channel, Biology, Neurotransmission
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