publication . Other literature type . Article . 2001

Bayesian Analysis of Haplotypes for Linkage Disequilibrium Mapping

Liu, Jun; Sabatti, Chiara; Teng, Jun; Keats, Bronya J.B.; Risch, Neil;
Open Access English
  • Published: 01 Oct 2001
  • Publisher: Cold Spring Harbor Laboratory Press
  • Country: United States
Abstract
Haplotype analysis of disease chromosomes can help identify probable historical recombination events and localize disease mutations. Most available analyses use only marginal and pairwise allele frequency information. We have developed a Bayesian framework that utilizes full haplotype information to overcome various complications such as multiple founders, unphased chromosomes, data contamination, and incomplete marker data. A stochastic model is used to describe the dependence structure among several variables characterizing the observed haplotypes, for example, the ancestral haplotypes and their ages, mutation rate, recombination events, and the location of th...
Subjects
free text keywords: Methods, Bioinformatics, Linkage Disequilibrium Mapping, Linkage disequilibrium, Gene, Allele, Haplotype, Biology, Genetics, Genetic marker, Allele frequency, Population, education.field_of_study, education
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