publication . Article . Other literature type . 1996

Apoptosis in Ischemic and Reperfused Rat Myocardium

Fliss, Henry; Gattinger, Deborah;
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  • Published: 01 Nov 1996 Journal: Circulation Research, volume 79, pages 949-956 (issn: 0009-7330, eissn: 1524-4571, Copyright policy)
  • Publisher: Ovid Technologies (Wolters Kluwer Health)
Abstract
Apoptosis has been observed previously in hearts subjected to either continuous ischemia or ischemia followed by reperfusion. The purpose of this study was to compare the timing and extent of apoptosis in both continuously ischemic and reperfused myocardium. We show that rats subjected to continuous coronary artery occlusion display characteristic signs of apoptosis solely in the ischemic myocardium after only 2.25 hours of ischemia, as illustrated by positive in situ end labeling (ISEL) of apoptotic cardiomyocyte nuclei in tissue sections and/or the presence of DNA “ladders” in agarose gels. In contrast, reperfusion after a 45-minute occlusion accelerated the p...
Subjects
Medical Subject Headings: cardiovascular diseases
free text keywords: Physiology, Cardiology and Cardiovascular Medicine, Programmed cell death, Coronary artery occlusion, Ischemia, medicine.disease, medicine, business.industry, business, Cardiology, medicine.medical_specialty, Apoptosis, Occlusion, Internal medicine, Myocyte, Reperfusion injury, Vascular disease
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