publication . Article . 2006

Multilevel analysis of systolic blood pressure and ACE gene I/D polymorphism in 438 Swedish families – a public health perspective

Råstam Lennart; Lindblad Ulf; Bengtsson-Boström Kristina; Merlo Juan; Melander Olle;
Open Access English
  • Published: 01 Mar 2006 Journal: BMC Medical Genetics, volume 7, pages 14-14 (eissn: 1471-2350, Copyright policy)
  • Publisher: BioMed Central
Abstract
<p>Abstract</p> <p>Background</p> <p>Individuals belonging to the same family share a number of genetic as well as environmental circumstances that may condition a common SBP level. Among the genetic factors, the angiotensin converting enzyme (ACE) gene I/D polymorphism appears as a possible candidate as it might influence both SBP and the pharmacological effect of ACE inhibitors. We aimed to combine genetic epidemiology with public health ideas concerning life-course and multilevel epidemiology in order to understand the role of familial factors regarding individual SBP.</p> <p>Methods</p> <p>We applied multilevel regression analysis on 1926 individuals nested ...
Subjects
free text keywords: Research Article, Genetics(clinical), Genetics, Internal medicine, RC31-1245, QH426-470, Angiotensin-converting enzyme, biology.protein, biology, Medical genetics, medicine.medical_specialty, medicine, Human genetics, Epidemiology, Polymorphism (computer science), Public health, Genetic epidemiology, Multilevel model
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