publication . Other literature type . Article . 2014

Genetic Prediction

Saad, Mohamad; Wijsman, Ellen M.;
Open Access English
  • Published: 01 Aug 2014
Abstract
In the last two decades, complex traits have become the main focus of genetic studies. The hypothesis that both rare and common variants are associated with complex traits is increasingly being discussed. Family-based association studies using relatively large pedigrees are suitable for both rare and common variant identification. Because of the high cost of sequencing technologies, imputation methods are important for increasing the amount of information at low cost. A recent family-based imputation method, GIGI, is able to handle large pedigrees and accurately impute rare variants, but does less well for common variants where population-based methods perform b...
Subjects
free text keywords: Article, Pedigree chart, Genetic association, Multivariate analysis, Imputation (genetics), Linkage disequilibrium, Imputation (statistics), Markov chain Monte Carlo, symbols.namesake, symbols, Biology, Statistics, Population, education.field_of_study, education
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