publication . Preprint . Other literature type . 2019

Slow recovery from inbreeding depression generated by the complex genetic architecture of segregating deleterious mutations

Paula E. Adams; John H. Willis; Patrick C. Phillips; Janna L. Fierst; Anna L Crist; Ellen Marie Young;
Open Access English
  • Published: 03 Dec 2019
  • Publisher: Cold Spring Harbor Laboratory
Abstract
<jats:p>The deleterious effects of inbreeding have been of extreme importance to evolutionary biology, but it has been difficult to characterize the complex interactions between genetic constraints and selection that lead to fitness loss and recovery after inbreeding. Viruses, bacteria, and the selfing nematode Caenorhabditis elegans have been shown to be capable of rapid recovery from the fixation of novel deleterious mutation, however the potential for fitness recovery from fixation of segregating variation under inbreeding in outcrossing organisms is poorly understood. C. remanei is an outcrossing relative of C. elegans with high polymorphic variation and ext...
Subjects
free text keywords: Selfing, Mutation Accumulation, Inbreeding, Biology, Reproductive success, Evolutionary biology, Small population size, Inbreeding depression, Outcrossing, Genetic architecture
57 references, page 1 of 4

Anderson, J. L., R. M. Reynolds, L. T. Morran, J. Tolman-Thompson, and P. C. Phillips. 2011. Experimental Evolution Reveals Antagonistic Pleiotropy in Reproductive Timing but Not Life Span in Caenorhabditis elegans. The Journals of Gerontology: Series A 66A:1300-1308. [OpenAIRE]

Baer, C. F., J. Joyner-Matos, D. Ostrow, V. Grigaltchik, M. P. Salomon, and A. Upadhyay. 2010. Rapid Decline in Fitness of Mutation Accumulation Lines of Gonochoristic (Outcrossing) Caenorhabditis Nematodes. Evolution 64:3242-3253. [OpenAIRE]

Barrière, A., S. P. Yang, E. Pekarek, C. G. Thomas, E. S. Haag, and I. Ruvinsky. 2009. Detecting heterozygosity in shotgun genome assemblies: Lessons from obligately outcrossing nematodes. Genome Res. 19:470-480.

Bell, D. A., Z. L. Robinson, W. C. Funk, S. W. Fitzpatrick, F. W. Allendorf, D. A. Tallmon, and A. R. Whiteley. 2019. The Exciting Potential and Remaining Uncertainties of Genetic Rescue. Trends Ecol. Evol. [OpenAIRE]

Brenner, S. 1974. Genetics of Caenorhabditis-Elegans. Genetics 77:71-94.

Burch, C. L. and L. Chao. 1999. Evolution by small steps and rugged landscapes in the RNA virus phi 6. Genetics 151:921-927. [OpenAIRE]

Charlesworth, B. and D. Charlesworth. 1999. The genetic basis of inbreeding depression. Genet. Res. 74:329-340. [OpenAIRE]

Charlesworth, D. 2006. Evolution of Plant Breeding Systems. Curr. Biol. 16:R726-R735.

Charlesworth, D. and B. Charlesworth. 1987. Inbreeding Depression and Its Evolutionary Consequences. Annu. Rev. Ecol. Syst. 18:237-268. [OpenAIRE]

Charlesworth, D., M. T. Morgan, and B. Charlesworth. 1993. Mutation Accumulation in Finite Outbreeding and Inbreeding Populations. Genetics Research 61:39-56.

Charlesworth, D. and J. H. Willis. 2009. FUNDAMENTAL CONCEPTS IN GENETICS The genetics of inbreeding depression. Nature Reviews Genetics 10:783-796.

Cutter, A. D., S. E. Baird, and D. Charlesworth. 2006. High nucleotide polymorphism and rapid decay of linkage disequilibrium in wild populations of Caenorhabditis remanei. Genetics 174:901-913.

Darwin, C. 1896. The variation of animals and plants under domestication. D. Appleton and company, New York,.

Denver, D. R., D. K. Howe, L. J. Wilhelm, C. A. Palmer, J. L. Anderson, K. C. Stein, P. C. Phillips, and S. Estes. 2010. Selective sweeps and parallel mutation in the adaptive recovery from deleterious mutation in Caenorhabditis elegans. Genome Res. 20:1663-1671.

DePristo, M. A., E. Banks, R. Poplin, K. V. Garimella, J. R. Maguire, C. Hartl, A. A. Philippakis, G. del Angel, M. A. Rivas, M. Hanna, A. McKenna, T. J. Fennell, A. M. Kernytsky, A. Y. Sivachenko, K. Cibulskis, S. B. Gabriel, D. Altshuler, and M. J. Daly. 2011. A framework for variation discovery and genotyping using next-generation DNA sequencing data. Nat. Genet. 43:491-+. [OpenAIRE]

57 references, page 1 of 4
Abstract
<jats:p>The deleterious effects of inbreeding have been of extreme importance to evolutionary biology, but it has been difficult to characterize the complex interactions between genetic constraints and selection that lead to fitness loss and recovery after inbreeding. Viruses, bacteria, and the selfing nematode Caenorhabditis elegans have been shown to be capable of rapid recovery from the fixation of novel deleterious mutation, however the potential for fitness recovery from fixation of segregating variation under inbreeding in outcrossing organisms is poorly understood. C. remanei is an outcrossing relative of C. elegans with high polymorphic variation and ext...
Subjects
free text keywords: Selfing, Mutation Accumulation, Inbreeding, Biology, Reproductive success, Evolutionary biology, Small population size, Inbreeding depression, Outcrossing, Genetic architecture
57 references, page 1 of 4

Anderson, J. L., R. M. Reynolds, L. T. Morran, J. Tolman-Thompson, and P. C. Phillips. 2011. Experimental Evolution Reveals Antagonistic Pleiotropy in Reproductive Timing but Not Life Span in Caenorhabditis elegans. The Journals of Gerontology: Series A 66A:1300-1308. [OpenAIRE]

Baer, C. F., J. Joyner-Matos, D. Ostrow, V. Grigaltchik, M. P. Salomon, and A. Upadhyay. 2010. Rapid Decline in Fitness of Mutation Accumulation Lines of Gonochoristic (Outcrossing) Caenorhabditis Nematodes. Evolution 64:3242-3253. [OpenAIRE]

Barrière, A., S. P. Yang, E. Pekarek, C. G. Thomas, E. S. Haag, and I. Ruvinsky. 2009. Detecting heterozygosity in shotgun genome assemblies: Lessons from obligately outcrossing nematodes. Genome Res. 19:470-480.

Bell, D. A., Z. L. Robinson, W. C. Funk, S. W. Fitzpatrick, F. W. Allendorf, D. A. Tallmon, and A. R. Whiteley. 2019. The Exciting Potential and Remaining Uncertainties of Genetic Rescue. Trends Ecol. Evol. [OpenAIRE]

Brenner, S. 1974. Genetics of Caenorhabditis-Elegans. Genetics 77:71-94.

Burch, C. L. and L. Chao. 1999. Evolution by small steps and rugged landscapes in the RNA virus phi 6. Genetics 151:921-927. [OpenAIRE]

Charlesworth, B. and D. Charlesworth. 1999. The genetic basis of inbreeding depression. Genet. Res. 74:329-340. [OpenAIRE]

Charlesworth, D. 2006. Evolution of Plant Breeding Systems. Curr. Biol. 16:R726-R735.

Charlesworth, D. and B. Charlesworth. 1987. Inbreeding Depression and Its Evolutionary Consequences. Annu. Rev. Ecol. Syst. 18:237-268. [OpenAIRE]

Charlesworth, D., M. T. Morgan, and B. Charlesworth. 1993. Mutation Accumulation in Finite Outbreeding and Inbreeding Populations. Genetics Research 61:39-56.

Charlesworth, D. and J. H. Willis. 2009. FUNDAMENTAL CONCEPTS IN GENETICS The genetics of inbreeding depression. Nature Reviews Genetics 10:783-796.

Cutter, A. D., S. E. Baird, and D. Charlesworth. 2006. High nucleotide polymorphism and rapid decay of linkage disequilibrium in wild populations of Caenorhabditis remanei. Genetics 174:901-913.

Darwin, C. 1896. The variation of animals and plants under domestication. D. Appleton and company, New York,.

Denver, D. R., D. K. Howe, L. J. Wilhelm, C. A. Palmer, J. L. Anderson, K. C. Stein, P. C. Phillips, and S. Estes. 2010. Selective sweeps and parallel mutation in the adaptive recovery from deleterious mutation in Caenorhabditis elegans. Genome Res. 20:1663-1671.

DePristo, M. A., E. Banks, R. Poplin, K. V. Garimella, J. R. Maguire, C. Hartl, A. A. Philippakis, G. del Angel, M. A. Rivas, M. Hanna, A. McKenna, T. J. Fennell, A. M. Kernytsky, A. Y. Sivachenko, K. Cibulskis, S. B. Gabriel, D. Altshuler, and M. J. Daly. 2011. A framework for variation discovery and genotyping using next-generation DNA sequencing data. Nat. Genet. 43:491-+. [OpenAIRE]

57 references, page 1 of 4
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