publication . Article . Other literature type . 2013

Omega-3 fatty acids and inflammation

Torrinhas, Raquel S.; Calder, Philip C.; Waitzberg, Dan L.;
Open Access
  • Published: 05 Feb 2013 Journal: British Journal of Clinical Pharmacology, volume 75, pages 645-662 (issn: 0306-5251, Copyright policy)
  • Publisher: Wiley
Abstract
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are n-3 fatty acids found in oily fish and fish oil supplements. These fatty acids are able to inhibit partly a number of aspects of inflammation including leucocyte chemotaxis, adhesion molecule expression and leucocyte-endothelial adhesive interactions, production of eicosanoids like prostaglandins and leukotrienes from the n-6 fatty acid arachidonic acid, production of inflammatory cytokines and T cell reactivity. In parallel, EPA gives rise to eicosanoids that often have lower biological potency than those produced from arachidonioc acid and EPA and DHA give rise to anti-inflammatory and inflammation...
Subjects
Medical Subject Headings: lipids (amino acids, peptides, and proteins)
free text keywords: Pharmacology (medical), Pharmacology, Arachidonic acid, chemistry.chemical_compound, chemistry, Biology, CYP2C8, Docosahexaenoic acid, GPR120, Eicosapentaenoic acid, Fish oil, Fatty acid, chemistry.chemical_classification, Eicosanoid, Nutrition and Dietetics, Medicine (miscellaneous), Nutraceuticals Themed Section, Letter to the Editor
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